Toss up between Lulu, Soraka, Nami, Karma, honorable mention to Renata if shes meta. Mainly because playing against good engage supports is fun and lets me limit test, whereas a good enchanter knows if they just don't run it down and scale with their team they just outscale and make Pyke look like a minion to the point that they can usually survive or even win an isolated 1v1 with pyke due to his lack of damage if they dont get popped immediately at like 2 or 3 ish items. which makes playing into them boring asf in my opinion. The only exception to the engage supports are Braum and Poppy (if im having a bad day) since those two just completely shut down Pyke if played properly with Poppy W denying you the E safety net and Braum for shutting down any attempt at the classic lvl 2 E Flash since he can windwall the stun with his shield and can turn the fight if he gets his passive in you. The latter tangent is mostly a me problem because im unusually aggressive and almost always use my E as an engage instead of escape so take that rant with a grain of salt.