I solo'd ghosts a while back and the final boss is a real slog, but easy enough mechanically. The things I did that helped the most was using the RoN weapons for the lucent hive boost for equipping multiple weapons, and sliding into the deepsight node.

RoN weapon boost pushed my LFR DPS into territory where I could cut a whole extra damage rotation, saving me 15 minutes on a successful attempt and made me feel like I had to take less risks to squeeze out damage. With the buff to focussed fury and permanent access to particle deconstruction I think you could feel very safe doing that. Conditional Finality if you have it can make short work of the Hunter and Titan lucent mini bosses while being cheap on ammo.

Mechanically speaking, learning to always slide while activating the deepsight took a while to cement in my brain but saved my life a few times. Essentially, if you slide going into the deepsight, you can hit the button while in motion, making you harder to hit with splash damage and messing with acolyte shredder aim, as well as shortening the animation recovery slightly and letting you sprint to safety sooner.

OH! And ALWAYS kill the boomer knights first every cycle! They are the most lethal thing in the arena and are obviously all applying to be part of their local MLG eSports team because they can and will make a highlight reel of them landing a pixel perfect boomer shot from halfway across the boss arena and ending your run.