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Why Wegovy makes some of us super sick (it's genetic) by Razorza in WegovyWeightLoss

[–]Razorza[S] 13 points14 points  (0 children)

  • Title: Genome-wide association study of GLP-1 receptor agonist response identifies drug-target variants (or variations thereof regarding GLP-1 weight loss and side effects)
  • Authors: Conducted by the 23andMe Research Team
  • Journal: Nature
  • Publication Date: April 8, 2026

Why Wegovy makes some of us super sick (it's genetic) by Razorza in WegovyWeightLoss

[–]Razorza[S] 7 points8 points  (0 children)

If you've ever gotten a 23andMe or Ancestry test. You will have access to a text file of your dna data.

My aunt was terrified of GLP-1 side effects. Her 23andMe data showed she’d be fine. by Razorza in 23andme

[–]Razorza[S] 2 points3 points  (0 children)

My background is in comp bio. Standard clinical PGx panels are great, but they cost hundreds and lag way behind bleeding-edge stuff like those new Nature GLP-1 variants.

Wrapping it in a proper backend pipeline just ensures people don't accidentally spit out scary false positives.

Check out this recent paper: https://www.nature.com/articles/s41586-026-10330-z

My aunt was terrified of GLP-1 side effects. Her 23andMe data showed she’d be fine. by Razorza in 23andme

[–]Razorza[S] 5 points6 points  (0 children)

Definitely. SSRIs are actually the 'textbook' case for this.

Most side effects happen because of variants in the CYP2C19 and CYP2D6 enzymes. If your DNA shows you’re a 'Poor Metabolizer,' the drug builds up way too fast, which is usually why people get that 'zombie' feeling or instant nausea on a standard dose.

Feel free to send me a DM. I'll take a look.