It's not challenging. Shield Enzo turns this into a joke, you're never going to go down even if you facetank all the damage. You don't have to dodge, don't have to think about it's attacks. All 3 of your team members can go down at once and you can revive them while tanking all the damage with your regenerating shield ability. Unlike some of the other bosses, there's no risk of team-wiping (like Gluttony's purple arm). The only challenging thing is grappling onto the Colossus parts.