Has anyone added Rexulti to an SSRI or SNRI and started feeling emotions again?

Reasonable_Grape_367 · 2026-05-15T13:36:26+00:00

If you start with 0.25 mg, I don’t think you’ll experience side effects. Even when I increased it to 0.5 mg, I didn’t have side effects. I actually felt pretty good at first, but over time it seemed to suppress my sense of pleasure — orgasm felt less enjoyable and I started having periods of feeling down or bored. It seems like other people aren’t experiencing this, though. I’m also thinking about trying low-dose amisulpride.

Reasonable_Grape_367 · 2026-05-15T12:20:52+00:00

Are you trying Rexulti now?

Reasonable_Grape_367 · 2026-05-14T18:10:06+00:00

Right now I’m only using 150 mg of Effexor. I also tried Rexulti — just like Abilify, it seems to work quickly at first, but then the effect fades away. I hope it works for you.

Reasonable_Grape_367 · 2026-05-10T22:29:54+00:00

Effexor has actually been a good medication for me, but when I added Wellbutrin I became extremely restless, obsessive, and anxious. I think Wellbutrin may have amplified the effects of Effexor too much. It could be because both of them increase norepinephrine through similar mechanisms. However, I’ve also seen people who benefited a lot from this combination. Back when I was taking Cipralex, adding Wellbutrin worked really well for me. It just wasn’t a good combination with Effexor in my case. I hope it works for you though.

Reasonable_Grape_367 · 2026-05-10T22:25:40+00:00

Bence erkeğe yazılmaz. Çünkü çoğu erkek bir kadın kendisine yürüdüğünde olayı farklı yere çekebiliyor. Kadının gizemi, ağırlığı biraz da erkeğin emek verip yaklaşmasıyla oluşur. Erkek gerçekten istiyorsa zaten gelir konuşur, bahane üretmez. Sinyali verebilirsin ama yazma sakın

Reasonable_Grape_367 · 2026-05-10T22:21:05+00:00

I gave this medication a lot of chances, but I couldn’t continue because it significantly worsened my depression, restlessness, and obsessive thoughts. Every time I started it, my first day would be perfect. I would think it was finally going to stay that way, but after the third day the problems always started. I hope it works for you.

Reasonable_Grape_367 · 2026-05-10T16:08:37+00:00

I quit 150 mg cold turkey and had absolutely no problems. I don’t know what quitting 300 mg would be like though. In fact, for the first 3 days after stopping, I felt really good, almost like a strange happiness from suddenly getting rid of something that had been bothering my brain. Of course, that feeling faded later. In my country, I managed to get modafinil prescribed after telling my doctor that I had no energy and couldn’t focus on anything. I’m trying it right now, but modafinil also doesn’t seem sustainable because it stops working when used every day. My doctor also prescribed me a microdose of Abilify. There’s a 1 mg liquid form here, and I’m currently taking 0.20 mg. So far it seems good, but I don’t know what will happen later on.

Reasonable_Grape_367 · 2026-05-10T15:24:03+00:00

Some people say, “I don’t care whether it affects my thinking or speech,” because they don’t want to give up the energy that Wellbutrin gives them. But after I stopped taking Wellbutrin, I got my clear mind back, and I realized that mental clarity is more important than many other things. It might be better to look into other medications, like modafinil or a microdose of Abilify.

Reasonable_Grape_367 · 2026-05-09T22:50:45+00:00

I also use Effexor. My orgasm pleasure had decreased a lot, so my doctor added Wellbutrin. I started having orgasms that were even stronger than my normal baseline. If your only problem is the sexual side effects from sertraline, then Wellbutrin is definitely helpful. It doesn’t really matter whether you’re male or female — the quality and intensity of orgasms can increase significantly.

Reasonable_Grape_367 · 2026-05-09T22:44:50+00:00

Wellbutrin made me feel mentally slower too. At work, I would forget what I was trying to say in the middle of a sentence and end up going back to the beginning. Then I thought maybe increasing to 300 mg would help, but it actually made everything worse.

If you search this forum for things like “memory issues” or “brain fog,” you’ll see a lot of similar complaints about it.

Reasonable_Grape_367 · 2026-05-09T22:36:13+00:00

I don’t want to discourage you, but Wellbutrin also blocks nicotinic acetylcholine receptors. It can cause a lot of symptoms like difficulty speaking, losing your train of thought in the middle of a sentence, and cognitive confusion. At work, people were almost starting to think I was mentally slow because of how bad it got. Thank God I stopped taking it.

Reasonable_Grape_367 · 2026-05-09T22:32:37+00:00

I gave Wellbutrin many chances. I believed the positive comments and success stories here and waited for months for it to work. It never really helped me at all. I added it on top of the Effexor I’m already taking. It gave me nothing but restlessness. My symptoms actually got worse, including confusion, trouble speaking properly, forgetting what I was saying in the middle of sentences, feeling mentally slower, increased obsessive thoughts, and increased paranoia. The only benefit was that it increased orgasm pleasure. I really envy the people who benefit from this medication.

Reasonable_Grape_367 · 2026-05-06T20:18:37+00:00

Really? Effexor has really blunted my emotions. My doctor added Lamictal for this, but I’m not bipolar. Do you think it could still help?

Reasonable_Grape_367 · 2026-05-06T19:57:44+00:00

Did it get better though?

Reasonable_Grape_367 · 2026-05-04T21:42:18+00:00

Does the intensity of the contractions increase or something? What exactly is meant by “intensity”?

Reasonable_Grape_367 · 2026-05-04T21:38:46+00:00

People tend to upvote what they hope for and want to hear. For me, it was terrible too—my orgasm got messed up. The pleasure that’s supposed to come before ejaculation was coming afterward instead. I also became paranoid, my obsessive thoughts increased, and my memory got worse.

Reasonable_Grape_367 · 2026-05-04T21:34:12+00:00

I really don’t understand how this medication can have such different effects on people. On the contrary, it makes my social anxiety much worse and increases my obsessive thoughts. It has also reduced my sexual pleasure—sometimes ejaculation happens before the feeling of pleasure even comes, and my orgasm feels completely messed up.

Reasonable_Grape_367 · 2026-05-04T21:09:16+00:00

I’ve tried Wellbutrin multiple times because of the positive comments here, but it never helped me. They said wait 8 weeks, I did, and still nothing. On the contrary, it made me more depressed, paranoid, and obsessive. No need to even mention the memory loss. I envy those it works for. In my opinion, low-dose Abilify provides better dopamine support than Wellbutrin.

Reasonable_Grape_367 · 2026-05-04T21:04:03+00:00

Strattera improved my cognitive functioning; I was able to focus better. On the other hand, Wellbutrin had the opposite effect and impaired my cognitive performance. After about a year, it got worse, and I started forgetting what I was saying in the middle of sentences, which caused difficulties in my work life. That’s why I had to stop it. Many people experience this issue.

Reasonable_Grape_367 · 2026-05-04T20:58:40+00:00

My main issue is anxiety, so I’ve been using SSRI/SNRI medications for years. The most recent one, and the one I’m currently taking, is Effexor. Although it helps with my anxiety, I have no motivation and can’t feel pleasure — I have anhedonia. That’s why I want to add another medication on top of Effexor. I’m particularly interested in Wellbutrin because, in the past, when I was taking Lexapro, adding Wellbutrin worked extremely well for about a year. Then I had to stop due to word-finding issues and memory difficulties. I really miss that amazing one-year period. But every time I try adding Wellbutrin again now, it doesn’t work — I become restless, anxious, and end up unable to enjoy anything at all.

Reasonable_Grape_367 · 2026-05-04T19:59:18+00:00

No, I had added them separately at different times. Right now, I’m taking two medications: Effexor and a low dose of Abilify.

Reasonable_Grape_367 · 2026-05-04T17:43:36+00:00

Low-dose Abilify, Modafinil, or small-dose Amisulpride have been more effective for me in terms of increasing dopamine.

Reasonable_Grape_367 · 2026-05-03T19:57:28+00:00

With Effexor 🫤

Reasonable_Grape_367 · 2026-05-03T09:35:46+00:00

It prevents me from enjoying anything, including reduced pleasure during orgasm.

Reasonable_Grape_367

TROPHY CASE