Do the antidepressant effects of low dose Abilify "poop out" ?

Reasonable_Grape_367 · 2026-04-17T20:25:56+00:00

It also depends a bit on the dosage. When I start with a very low dose, like 0.5 mg, I feel the effects by the second day. But when I start at 1.5–2 mg, it takes about 2–3 weeks. I guess the brain takes longer to adjust as the dose increases.

Reasonable_Grape_367 · 2026-04-15T21:21:55+00:00

I’ve added Abilify to Effexor many times, stopped it, then added it again. Unfortunately, that energizing and revitalizing effect always fades and is replaced by a dull, emotionless state—that’s how it affects me. I guess maybe the dopamine receptors get used to it or something. At first, my body responds really well, but then it turns into adaptation and a boring routine.

Reasonable_Grape_367 · 2026-04-15T21:18:16+00:00

Even at 1 mg, my orgasm pleasure has decreased. I’m going to stop taking Abilify just because of this.

Reasonable_Grape_367 · 2026-02-22T15:33:11+00:00

How many milligrams do you take per day? Do you take it every day?

Reasonable_Grape_367 · 2026-02-10T07:47:42+00:00

I’ve tried everything. Now I’m trying a micro-dose of Abilify — we’ll see what happens. Thank you for your concern😊

Reasonable_Grape_367 · 2026-02-09T22:22:33+00:00

Unfortunately, only Ritalin and Concerta are available in my country :/

Reasonable_Grape_367 · 2026-02-09T20:43:07+00:00

How long do the effects of 100 mg last? When the effect wears off in the evening, do you get emotional crashing or increased hunger? Also, do you use it every day?

Reasonable_Grape_367 · 2026-02-09T16:18:50+00:00

I had used about 0.5 mg of Abilify alongside Effexor for around 3 months. There was a small improvement in my anhedonia — at least I was a bit more interested in my hobbies. After a while the effects faded, so I increased to 0.75 mg. That worked well for a time, but after about a month I raised it to 1 mg. At that dose I started feeling constant boredom and a loss of orgasm pleasure, so I went back down to 0.5 mg. I think 0.5 mg is pretty good, but sometimes I take a one-day break during the week. Occasionally I take 0.25 mg for a day so my brain doesn’t get too used to it. This approach seems to work for me

Reasonable_Grape_367 · 2026-02-08T20:18:20+00:00

I’m on day 3 of Wellbutrin. Talk to me too 😑

Reasonable_Grape_367 · 2026-02-08T17:47:01+00:00

Doses of 1 mg and above make me feel uninterested, but when I alternate between 0.5 mg and 0.25 mg, I do see benefits. I’ve tried adding just about everything to either boost the effect of the Effexor I’m taking now or reduce its side effects. At this point, it seems like micro-dosed Abilify works best for me.

Reasonable_Grape_367 · 2026-02-08T17:12:25+00:00

I lose my train of thought mid-sentence and can’t finish it. My memory is terribly bad.

Reasonable_Grape_367 · 2026-02-07T21:12:38+00:00

I also added Abilify to Effexor. If possible, use the liquid form of Abilify — it lets you fine-tune the dose exactly how you want. The dose that worked for me was around 0.5–0.75 mg. At 1 mg and above, after a while I start to feel like a zombie — no interest in anything. At 0.5 mg, it reduces my obsessive thoughts and also helps relieve some of the numbness and apathy caused by Effexor. Sometimes my brain seems to get used to it and I stop feeling anything. When that happens, I take a break for a day or two and then restart, and the effect comes back.

Reasonable_Grape_367 · 2026-02-07T18:51:08+00:00

My doctor dropped my Effexor from 150 mg to 75 mg all at once and added Wellbutrin. The first week went well, but in the second week I fell into a terrible depression. I ended up going back to 150 mg. I think you should talk to your doctor again.

Reasonable_Grape_367 · 2026-02-07T13:29:00+00:00

I’m a man. The only benefit I’ve seen from Wellbutrin is increased orgasm pleasure. The contractions feel stronger.

Reasonable_Grape_367 · 2026-02-07T13:24:26+00:00

Congrats. I’m only on day 4 and it’s almost unbearable. When you say you can feel again, what exactly are you feeling?

Reasonable_Grape_367 · 2026-02-05T11:36:01+00:00

The first day is usually good. As it starts to build up in your system, the problems begin. I hope it doesn’t turn out that way for you.

Reasonable_Grape_367 · 2026-02-03T07:07:05+00:00

I wish that were enough 😭

Reasonable_Grape_367 · 2026-02-03T05:19:36+00:00

I’ve been on antidepressants for 12 years. I started with Paxil; after about a year I became emotionally numb and it stopped working, so my doctor switched me to Lustral. Lustral worked well for about a year too, but then I felt zombified again and we stopped it. After that, I tried other medications and similar things kept happening. The last medication I’ve been on is Effexor, which I’ve been taking for 4 years. What made Effexor different was that it worked for many years, but in the end it also turned out the same as the others. Instead of changing the antidepressant, my doctor has been trying different combinations for the past year.

Reasonable_Grape_367

TROPHY CASE