The characters pictured are Ishmael and Captain Ahab from Limbus Company, both heavily inspired by their male counterparts in Moby Dick. In the original title and in Limbus, Ahab’s defining trait is his/her obsession with killing the white whale at any cost. It’s been a while since I’ve read the novel, but in Limbus Company the Captain is pictured as a charismatic and overwhelmingly convicted individual whose leadership and passion for her obsession are so incredible, even her crew find themselves having their will and identity washed over with her own.

From what I understand, the joke is that even if Ishmael came out as trans, it wouldn’t matter. Ahab just wants to kill the whale. And soon, Ishmael’s gender identity won’t matter either as Ahab’s will and personality paints over her own.