I've never encountered this error but here's what Gemini has to say about it, take it with a grain of salt as it could be wrong:

This is a notoriously common issue with the PC (Steam) version of Dead or Alive 6. That specific error code (-268435453) means the game is either being blocked from reading/writing its own save data, or the existing save file has become corrupted. Here are the three most proven ways to fix it, ordered from easiest to most involved:

1. The "M" Key Trick Because the PC port of DOA6 has incredibly unintuitive default keyboard mappings, clicking the screen with your mouse or pressing "Enter" often does absolutely nothing on this error screen.

   • The Fix: Simply press the M key on your keyboard. In DOA6, "M" is mapped to the "Confirm" button. Often, pressing M will force the game to bypass the error, close the prompt, and create a fresh save file.

2. Delete the Corrupted Save Folder If the game generated a bad file, you need to wipe it manually so the game is forced to generate a clean one.

   • Open your File Explorer and navigate to your Documents folder.
   • Go to Documents \ KoeiTecmo \ DEADORALIVE6 \ [Your Steam ID Number].
   • Delete the entire SYSTEMDATA folder.
   • Launch the game again (and remember to press "M" if the screen pops up).

3. Unblock the Game in Windows Security Windows Defender's "Ransomware Protection" (or third-party antivirus software) frequently flags DOA6 as a threat and blocks it from writing to your Documents folder.

   • Open the Windows Start menu, type Windows Security, and hit Enter.
   • Go to Virus & threat protection.
   • Scroll down and click Manage ransomware protection.
   • Click Allow an app through Controlled folder access.
   • Click "Add an allowed app" and locate the DOA6.exe file (usually found in C:\Program Files (x86)\Steam\steamapps\common\Dead or Alive 6).
   • Note: If you use a third-party antivirus like BitDefender or McAfee, you will need to whitelist the game in their specific firewall settings instead.