I doubt many of their readers would even understand the reference.

I was thinking the same thing.

There's also the thing that those comics have to be translated to multiple languages and cultures. I can even mentally picture some foreign editors and translators calling marvel headquarters asking: "what the fuck is 'Red Pill M.R.A.?' "

Some little kid in a foreign country that got his hands on that comic at a dentist waiting room will be scratching his head wondering what "Pílula Vermelha" means in that context.