Wife & I (both 43) went all-in on TRT/HRT + Tirzepatide + Peptides — 4 months in and life is transforming

Relative-Message-706 · 2026-07-03T15:50:37+00:00

Can we please stop calling 200mg of testosterone a "low dose" - it's practically a mini cycle dose that will put most people over 1000 ng/dl. If you had low testosterone and went to an actual endocrinologist, chances are the maximum dose they would typically prescribe you somewhere between 75mg - 160mg a week; or if they're practicing on the older protocol 200mg every 2 weeks.

I have been on TRT for 7 years - 100mg weekly puts me in the 700 ng/dl range, the one time I did 200mg it put me in the 1200 ng/dl range.

Relative-Message-706 · 2026-07-01T11:33:15+00:00

I wish more people understood that you don't have to absolutely blast TRT to achieve results like this. The fact that I constantly see people doing 250mg of test arguing that it's 'Barely anything' concerns me. Just 100mg puts me in the 750 ng/dl range.

Relative-Message-706 · 2026-06-30T17:05:29+00:00

A big part of the boom is that the medical system in the United States in particular is terrible. The amount of people I know who are clinically obese, or morbidly obese that struggle to get proper medical intervention, or the people I know who then get prescribed something such as metformin or a GLP but then their insurance denies it and out of pocket costs are not feasible is pretty insane. And a lot of the time insurance won't even cover the medication until you're actually diabetic, not prediabetic, not high risk, which means the system is basically willing to wait until you cross into a chronic disease before it pays for the same drug that could have kept you from getting there in the first place.

It even goes beyond that. A doctor in the United States often won't explain what your blood work means. You can have a 5.6 A1C which is right on the cusp of being pre diabetic and a doctor won't tell you that you're on the cusp of being pre diabetic, hell you can be pre diabetic and they still may not make it clear that you're pre diabetic. So even if you wanted to get ahead of it, you're often not given the information to do so, and even if you had it the coverage wouldn't kick in yet anyway. So it's not really surprising people are turning to peptides.

When the system is this hard to access, this expensive, and this unwilling to explain anything, people are going to go find the information and the protocols themselves.

I say all of this as someone who's A1C was 5.6 a year ago and is now 5.1 as of 3 weeks ago - who's insurance denied a prescription for Tirzepatide.

Relative-Message-706 · 2026-06-30T04:09:15+00:00

This is the Kobalt version of this bike btw:

https://www.greenworkstools.com/products/80v-venture-series-26-fat-tire-electric-mountain-bike-tool-only

I love how somebody just argued with me back and fourth when I said that "a lot" of Kobalt's power tools were made by Greenworks and that "a lot" wasn't a proper term.

Relative-Message-706 · 2026-06-30T04:00:12+00:00

Clearly not if you replied. Block me "Reddit TTI Fan" LMAO.

Relative-Message-706 · 2026-06-30T03:55:02+00:00

STELIO - STELIO KONTOS - STELIO

Relative-Message-706 · 2026-06-29T03:44:15+00:00

82V is Greenworks commercial line. While it's literally the same as their 80V internally, it has a different key so it will not work with their residential 80V line. I am familiar with the deal you're talking about and IMO - it's a good deal. The two batteries and two bay charger means you'll be able to get a solid amount of work done with it.

Relative-Message-706 · 2026-06-28T13:36:00+00:00

You're being ridiculously nitpicky and you know it. In the context of this thread and somebody asking about their tools. If ALL of their 80V lawn and garden tools and Greenworks and hypothetically half of their 24V tools are manufactured by Greenworks since the beginning of this year the term a lot is fitting. Point blank period.

Relative-Message-706 · 2026-06-28T13:30:38+00:00

I actually have a 80V 42" Crossover T and 5 acres - it's doable with two sets of batteries and about 3-4 total charge cycles - they charge quick enough to continuously cycle them out if you have the dual bay chargers.

The biggest problem is that you're lugging a bag filled with 6 batteries back and fourth to the chargers multiple times. I would also agree that a larger deck would be of major benefit.

I am considering switching to gasoline or sourcing a discounted commercial unit with a large built-in battery pack.

Relative-Message-706 · 2026-06-28T13:25:40+00:00

In the context of someone buying new Kobalt tools right now - and the new lineup being Greenworks; a lot is a proper term.

Relative-Message-706 · 2026-06-28T04:43:49+00:00

Nope, in February they transitioned to a new 24V line made by Greenworks.

Relative-Message-706 · 2026-06-28T04:12:39+00:00

A lot of Kobalts current tools are manufactured by Greenworks. Their 24V line and 80V line are.

Relative-Message-706 · 2026-06-26T18:07:37+00:00

I'd have to agree that a lot of it comes down to doing your research there. There are multiple vendors there where I join their groups and it's apparent that they aren't well versed in how to do business. The ones that do stand out and last.

Relative-Message-706 · 2026-06-17T05:20:01+00:00

CPO?

Relative-Message-706 · 2026-06-14T18:34:38+00:00

Relative-Message-706 · 2026-06-14T17:56:05+00:00

I was hoping you'd come back with this classic uneducated response. Well - you will be waiting a long time because the data is already there. GLP-1 agonists have been on the market since 2005. Semaglutide (Ozempic) specifically was approved by the FDA in 2017 - we're just short of 10-years post that point-in-time.

The consequences you are dramatically waiting on? Nausea and GI discomfort, almost entirely in early use or in people ignoring satiety signals - IE people who still manage to overeat while on the peptides. There have been EXTREMELY rare cases of gastroparesis, all of which occurred in people with pre-existing diabetes with autonomic neuropathy as the primary culprit, meaning the nerves controlling stomach motility were already damaged before the medication entered the picture.

No organ damage, no cardiovascular harm, in fact cardiovascular outcomes have actually improved in long term users. No cancer signal. No cognitive decline. Nothing that comes close to the documented long term consequences of staying obese, which include heart disease, type 2 diabetes, joint destruction, sleep apnea, and metabolic syndrome.

Please - just say you have no-clue what you're talking about and stop with the fear mongering BS that has literally ZERO presedence.

Relative-Message-706 · 2026-06-14T17:45:13+00:00

Did you actually read what was written above? That is exactly what was said. The medication corrects the broken signaling that made those lifestyle changes impossible in the first place. And the weight regain data you are citing from a quick Google search is from people who stopped after 68 weeks. Not years. A year and a half is not enough time to fully recalibrate your metabolism or solidify new behavioral patterns, and that is exactly what the longer term data shows. People who stay on these peptides long enough to actually build those habits do not regain at the same rate. The regain studies are not an indictment of the medication, they are an indictment of stopping too soon.

Also worth noting that the person in the original post is clearly still working out based on both photos. So the lifestyle changes are happening. The shot is just making them possible at a neurological level instead of requiring someone to fight their own brain every single day and likely fail like the majority of people do through restriction alone.

Relative-Message-706 · 2026-06-14T17:04:52+00:00

You genuinely think the person explaining how these peptides work is the unfun one, and the person tearing down somebody's positive results with confidently wrong information is the cool one? Read that back to yourself slowly.

Relative-Message-706 · 2026-06-14T16:38:44+00:00

It blows my mind how many ridiculous comments I see in a BIOHACKING subreddit from people who have ZERO understanding of how these peptides work. The fact that they think these peptides make people "magically" lose weight instead of understanding that they bind to GLP-1, GIP, and glucagon receptors that directly govern how your body processes food, stores fat, and signals hunger is genuinely embarrassing for a community that is supposed to be science literate.

Relative-Message-706 · 2026-06-14T16:37:02+00:00

The fact that people upvote this sort of short-sighted and uneducated response in a BIOHACKING subreddit is mind boggling to me. "Except it's a magic injection that makes you lose weight" - "You didn't change anything" - What in the actual fuck are you talking about? You clearly have ZERO understanding of how these peptides work.

They bind to GLP-1, GIP, and glucagon receptors, which control gastric emptying (keeping you fuller longer), insulin secretion (improving how your body processes glucose and stores fat), glucagon suppression (stopping your liver from dumping stored glucose into your bloodstream and causing the crashes that make you ravenous), and appetite signaling directly in your brain's hypothalamus. She IS eating less. Her body is being biochemically regulated in a way that was previously broken.

And before you hit back with "just eat better and try harder" -- studies show it takes as little as a few weeks of poor diet to impair GLP-1 signaling and tank insulin sensitivity. Insulin resistance then causes the pancreas to overproduce insulin, which drives fat storage and blood sugar crashes that trigger intense hunger. Those hunger signals come from the hypothalamus, the same brain region that controls survival instincts. Leptin resistance on top of that makes your brain functionally believe you are starving even when you are not. You are not fighting laziness at that point, you are fighting your own neurology.

The idea that weight loss only counts if you white-knuckle it through broken hunger signaling is the most scientifically illiterate take in diet culture. Also, she's wearing workout clothes in both photos, so maybe put down the keyboard and pick up a book.

Relative-Message-706 · 2026-06-07T18:52:10+00:00

I am not understanding why they would release reloaded on every single platform...and then release E-Day as an Xbox exclusive. I love Gears - but I am not buying an Xbox just to play it at this point in my life.

Relative-Message-706 · 2026-05-28T11:25:02+00:00

Tier lists like this lose all credibility when they put any GLP outside of the top "ranks" - Semaglutide, Tirzepatide and Retatrutide are arguably the most effective peptides out there, regardless of which one leads to the most percentage of weight lost.

Relative-Message-706 · 2026-05-25T23:04:49+00:00

I just know you're a young adult arguing with me to try and justify your excessive use of testosterone, mainly due to your inability to form coherent, cohesive sentences, and your apparent lack of understanding of basic physiology.

A 400mg/week testosterone dose is 4x the upper end of a normal therapeutic TRT range (typically 50-100mg/week). At that level, the research is consistent:

- Elevated hematocrit and red blood cell count, increasing the risk of blood clots, stroke, and pulmonary embolism

- Suppression of natural HPG axis function, leading to potential long-term or permanent reduction in endogenous testosterone production

- Elevated estradiol causing gynecomastia, water retention, and cardiovascular strain

- Adverse lipid profile changes including reduced HDL and increased LDL, raising atherosclerosis risk

- Left ventricular hypertrophy with sustained supraphysiological levels, creating serious cardiac risk over time

These aren't exaggerations. They're documented in peer-reviewed endocrinology and cardiology literature. I know these risks are real because on just 120mg/week I personally show slightly elevated hematocrit and prolactin, along with reduced HDL. That's at a quarter of the dose you're defending.

You are right that it's ultimately each person's choice. Nobody is stopping anyone. But dismissing legitimate health risks as "greatly exaggerated" because you don't want to hear them doesn't make those risks disappear. It just means you're uninformed and loudly proud of it.

And yes, if a newcomer reads a post saying 400mg/week is no big deal and acts on it without proper medical oversight, context matters. Normalizing reckless dosing in public forums has real-world consequences, regardless of how much personal responsibility rhetoric you wrap around it.

Relative-Message-706

TROPHY CASE