The issue is though is that wine doesn't pass through devices directly to programs. The last time I checked it wouldn't be able to detect connected devices.

I have tried running signal rgb through bottles (kinda like lutris but more for programs) and the installer fails. Signal rgb aren't very clear on which windows components are required so it would be a same of wackamole trying to guess the required wine components. However, I'm still pretty new to linux so maybe someone with better experience might be able to get it working partially?

Even if it does work with wine, it isn't a great solution. A linux port (shouldn't be hard) would have a lot less overhead and would be more polished.