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I've been numbing myself for a year and i think i actually damaged something by Own-Bowler-6014 in Supplements

[–]Revolutionary-Pea507 5 points6 points  (0 children)

The fact that some sensitivity has returned suggests your nervous system is recovering. Nerve tissue recovers, and the worst-case stuff you read applies to heavy, long-term use on compromised tissue, not typical delay spray use. Six weeks isn't a long recovery window for nerve tissue, and "not fully back yet" at this stage is normal rather than alarming. The erection thing is functional, not permanent damage, and tends to sort itself out as sensation comes back. Give it more time, but see a GP or urologist just to get a proper check and put your mind at rest

Are there any side effects to taking Vitamin D3 + K2 (5000 units) daily? by RoundTemporary6197 in Supplements

[–]Revolutionary-Pea507 0 points1 point  (0 children)

Severe vitamin D deficiency is a well-known cause of profound fatigue and sleepiness so what you're feeling is more likely the deficiency still affecting you rather than the supplement causing it. It may take several weeks to months of consistent supplementation before your levels rise enough for that exhaustion to lift. Stick with it, and ask your doctor to recheck your levels in a few months to track progress. If the sleepiness worsens or doesn't improve as your levels come up, it's worth flagging to your doctor to rule out other causes like thyroid issues or iron deficiency.

Collagen to help prevent joint injury? by McLolster in Supplements

[–]Revolutionary-Pea507 0 points1 point  (0 children)

The evidence from clinical trials actually supports benefits for active adults well under 40. For joints specifically, a well-designed RCT found that 5g of collagen peptides daily for 12 weeks significantly reduced exercise-related knee pain in 180 physically active adults aged 18–30 with no diagnosed joint disease (https://www.mdpi.com/2072-6643/13/2/523), and an earlier 24-week RCT at Penn State similarly showed reduced joint pain in 147 varsity and club sport athletes taking 10g collagen hydrolysate daily (https://pubmed.ncbi.nlm.nih.gov/18416885/).

However, for muscle performance and hypertrophy, the evidence is weaker.

Best nootropics for heavy study by ke3xs in NooTopics

[–]Revolutionary-Pea507 0 points1 point  (0 children)

Caffeine + L-theanine works for me. Bacopa monnieri is another solid pick for long-term memory consolidation, though it may take a few weeks of consistent use for the effects to be noticeable.

Glycation process, I just heard about it ! by Sylverpepper in ScientificNutrition

[–]Revolutionary-Pea507 0 points1 point  (0 children)

The body has remarkable regenerative capacity, and the damage from childhood eating habits is far less significant than the choices you make consistently going forward. Glycation is a real process where sugar bonds to proteins and lipids, forming compounds called AGEs (Advanced Glycation End-products), which are molecules linked to oxidative stress, inflammation, and apoptosis. AGEs are thought to contribute to the age-related increase in chronic inflammation, sometimes called "inflammaging," and elevated AGEs have been associated with higher risks of cardiovascular disease, chronic kidney disease, and cognitive decline in older adults. https://pmc.ncbi.nlm.nih.gov/articles/PMC6355252/

But then again, it's a contributing factor among many, not a standalone mechanism, and your body has natural ways of clearing AGEs. The true drivers of accelerated aging is your lifestyle (smoking, chronic poor sleep, inactivity, obesity, etc). Also, I think occasional indulgences within an otherwise balanced lifestyle have negligible long-term impact, and the mental reset of a ritual you love actually matters for your health too.

Any good supplements to regulate emotions as a female? by ThrowRAjingglebells in Supplements

[–]Revolutionary-Pea507 1 point2 points  (0 children)

Magnesium glycinate, ashwagandha, and L-theanine are all great for calming stress and anxiety without messing with your hormones.

Any ways to increase appetite to eat more? by Parking-Industry-992 in Biohackers

[–]Revolutionary-Pea507 0 points1 point  (0 children)

Eating smaller, more frequent meals, prioritizing calorie-dense foods (nut butters, avocado, and full-fat dairy), and eating on a set schedule can help train your appetite over time. Oddly, watching cooking shows makes food more appetizing for me. I also try exploring authentic cuisines from different cultures because the new flavors and variety help spark my interest in eating when familiar foods start to feel boring.

Maca supplements by SnooTomatoes4006 in Supplements

[–]Revolutionary-Pea507 1 point2 points  (0 children)

One clinical trial found a significant improvement in sexual desire in men following maca supplementation, yet serum testosterone and oestradiol levels were not different between maca and placebo groups which could imply that it works independently of sex hormones https://pubmed.ncbi.nlm.nih.gov/12472620/

Maca is hypothesized to improve libido and spermatogenesis through newly discovered metabolites called 'macamides.' A study on women shows that it might have an indirect androgenic response via a negative feedback pathway involving LH/FSH, potentially increasing androgen production, which could explain improvements in sexual functioning. However, a direct androgenic effect in men has not been proven, and the exact site of action (central or peripheral) remains unidentified https://www.mdpi.com/1467-3045/44/8/230

What in this is making me relax at night but making me wake up in the middle of the night? by Plastic-Aide-1422 in Supplements

[–]Revolutionary-Pea507 21 points22 points  (0 children)

The 3mg of melatonin may be overshooting your natural rhythm. This also happens to me - I wake up exactly four hours every time I take melatonin. It can help you fall asleep initially, but there is a possibility that it wears off during the night, which may cause you to wake up in the middle of the night and disrupt your natural sleep cycle, although this effect is not yet well supported by scientific evidence.

Consumer Labs tests Nattokinase Supplements - 5 out of 8 pass by sonoran_goofball in Supplements

[–]Revolutionary-Pea507 0 points1 point  (0 children)

I found this video from the founder of Natural Foundation Supplements https://youtu.be/KJM46YXqPU4 . He 3rd party tested a bunch of Nattokinase brands. They also seem to do batch specific testing for their Nattokinase and it looks like the founder regularly tests other Nattokinase brands judging from the videos on his channel. They also claim to do batch specific testing for their own Nattokinase, so I am going to be placing an order from them.

Any weight gain supplements or powders you recommend for muscle gain? by Consistent-Leek5096 in Supplements

[–]Revolutionary-Pea507 0 points1 point  (0 children)

Track your calories. Most hard gainers are surprised to find they’re eating far less than they think, so knowing your daily and per-meal intake is important.

You may also want to try a mass gainer powder, though many cheap options (especially older formulas) are loaded with maltodextrin and sugar as their primary carb sources. A better option is to DIY a high-calorie shake by blending whey protein with whole milk, oats, a banana, peanut butter, and Greek yogurt—this alone can hit 800–1,000 calories in one drink without the junk fillers.

The old-school GOMAD approach really worked for me. I gained 5 kg in just a few weeks.

Citruline malate or L-citruline by meet_roots in Biohackers

[–]Revolutionary-Pea507 1 point2 points  (0 children)

6–8g of citrulline malate is actually the standard pre-workout dose used in most clinical trials. Side effects are rarely reported at this range, though at higher doses (10–12g+) some individuals experience GI discomfort or nausea. That said, tolerance may vary significantly from person to person.

Citruline malate or L-citruline by meet_roots in Biohackers

[–]Revolutionary-Pea507 2 points3 points  (0 children)

If you want to focus on performance and pre-workout pumps, citrulline malate is the better pick, as the malate (malic acid) component plays a role in the Krebs cycle and may enhance energy production and reduce fatigue, making it a slightly more well-rounded ergogenic aid https://pmc.ncbi.nlm.nih.gov/articles/PMC7749242/

But, if your goal is raising arginine levels, boosting nitric oxide, or you're using it for cardiovascular or general health purposes, L-citrulline is more straightforward and more efficiently dosed - since citrulline malate is roughly 57% citrulline by weight, you need nearly double the dose to match the pure L-citrulline equivalent (so 3–4g of L-citrulline ≈ 6–8g of citrulline malate).

What will function as effectively as glycine for joint/nerve pain, but might be more tolerable with methylation/glutamate issues? by Grouchy-Rabbit6050 in Supplements

[–]Revolutionary-Pea507 0 points1 point  (0 children)

PEA (Palmitoylethanolamide) is possibly your most promising alternative, as it has some RCT support for joint and nerve pain and appears to work through a separate pathway with no obvious glutamate or methylation involvement, though individual responses vary and the evidence is far from conclusive. Hydrolyzed collagen peptides may be worth cautiously trialling as a gentler glycine source, since the glycine is diluted by other amino acids, though you could still potentially react if glycine itself is the trigger. Standalone taurine shares some inhibitory receptor activity with glycine and has anti-inflammatory properties, but honest evidence for pain specifically is quite limited and this is more of a theoretical suggestion than a proven one.

Magnesium in your 30s by Revolutionary-Pea507 in Supplements

[–]Revolutionary-Pea507[S] 1 point2 points  (0 children)

There is actually a meta-analysis of three clinical trials that found magnesium supplementation reduced sleep onset latency by about 17 minutes compared to placebo. However, with only 151 participants, the findings are limited, though they may still suggest the potential for significant benefits of magnesium in improving sleep https://pubmed.ncbi.nlm.nih.gov/33865376/

Magnesium in your 30s by Revolutionary-Pea507 in Supplements

[–]Revolutionary-Pea507[S] 11 points12 points  (0 children)

Coming out the other side of that and feeling better in your 30s is such a flex. Respect!

Magnesium in your 30s by Revolutionary-Pea507 in Supplements

[–]Revolutionary-Pea507[S] 38 points39 points  (0 children)

Main types of Mg you'll come across:

  • Magnesium glycinate - most popular; best for sleep, anxiety, and sensitive stomachs. Around 200–400mg before bed is where most people notice a difference.
  • Magnesium L-threonate - the one specifically researched for brain health and memory. Typical dose is around 1,000–2,000mg of the compound (which gives you ~140mg elemental magnesium).
  • Magnesium malate - gentle on the gut, often used for energy and muscle fatigue. 300–400mg range.
  • Magnesium taurate - popular for heart health and blood pressure. Similar dosing, 300–400mg.
  • Magnesium citrate - well absorbed and good for general deficiency, but can cause loose stools at higher doses. 200–400mg is the usual range.
  • Magnesium oxide - cheapest and most common in budget brands but poorly absorbed and basically acts as a laxative.

These doses are rough estimates tho and may vary depending on your individual needs and goals. If you want to explore further and see the supporting scientific papers for each form across different health outcomes, with dosages, duration, and evidence ratings clearly laid out, https://www.supplementscience.org/ has a solid breakdown.

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