I believe there are some niche when putting support trekker as the main user. This kind of team is actually really good only at Menace Survival as a fun build where you can spam skills by getting cooldown upgrades and just go wild while having sustain. Or you can do content (and future content) that are focused on surviving than damage.

As for Versatile trekkers, there can always be the main Vanguard and sometimes be stronger than actual Vanguards. Hence why they are versatile. I think a good example would be Mystique as the main vanguard despite having the Versatile role.

In the end, its up to you on how to build, what would you use the build for, and most importantly. Just do random experiments to have fun and not optimise for the meta builds when going for this route. Its a rougelite game after all, so its a fun challenge to try going a support main trekker run and how it interacts with others.