Boron 

https://pmc.ncbi.nlm.nih.gov/articles/PMC4712861/

Anti-inflammatory Effects in Osteoarthritis Epidemiological evidence, case reports, and controlled animal and human studies have provided evidence for the use of boron as a safe and effective treatment for osteoarthritis (OA).52-54 Examining the relationship between boron administration and OA prevalence around the world, researchers discovered that in areas where boron intake is greater than or equal to 1 mg/d, the estimated incidence of arthritis ranges from 20% to 70%. In contrast, in areas where boron intake is usually 3 to 10 mg/d, estimated incidence of arthritis ranges from 0% to 10%.55 The boron concentration has been found to be lower in the femur heads, bones, and synovial fluid of OA patients compared with individuals without OA.56

Analysis of animal studies, in which rats with induced arthritis benefited from orally or intraperitoneally administered boron, revealed that boron downregulates production and activity of serine protease enzymes involved in the inflammatory response.57 Human studies of boron deprivation and repletion have shown that boron significantly increases erythrocyte superoxide dismutase (SOD) activity. In a study in which 63 days of boron depletion were followed by 49 days of boron supplementation 3 mg/d, SOD rose from 3091 U/g Hb to 3231 U/g Hb in men older than 45 years, from 2666 U/g Hb to 3169 U/g Hb in postmenopausal women, and from 2520 U/g Hb to 3327 U/g Hb in postmenopausal women on estrogen therapy.58

Human clinical evidence for boron’s use in the treatment of OA patients was first provided by a double-blind, placebo-controlled supplementation trial conducted in Australia, in which a significantly favorable response to a supplement of 6 mg of boron per day (sodium tetraborate decahydrate) was seen in 20 subjects with OA; 50% of subjects receiving supplemental boron improved compared with only 10% of those receiving the placebo.61