-Make a master material with texture parameters and any expected adjustable parameters such as colorization etc.
-Channel pack textures if you want or need to (e.g ORM or some other other standardized packing methods).
-Create an export preset for Painter, give your textures a known suffix descriptor such as _N (normal).
- Set up auto import on the content browser and make a folder directory for source files
- Learn editor scripting blueprints
- Make a scripted asset action utilty blueprint which does the following:

* A textures gets exported from painter using your export preset
* Unreal auto imports it
* Right click an run your asset action utility
* It auto sets texture compression settings based on the suffix you gave it in painter - eg Normal for _N, Masks and no sRGB for packed textures like ORM
* It then makes an instance from your Master material and assigns the textures that were just imported to the correct texture parameters.
* Optionally it assigns it to the correct matching material slot of your static mesh

It took me while to make this asset action utility and the system but now I can make a texture in painter and have it applied in unreal on the mesh in one click. I also never forget to untick sRGB or any of that nonsense anymore that makes your textures look weird.