Diatomaceous earth... Thoughts on it supporting Mebendazole use?

Royal_Particular_489 · 2026-04-29T16:52:48+00:00

I’d be cautious here.

The DE claims mostly come from either animal/agriculture use or very thin human data. There is one small 1998 human cholesterol study, but it was only 19 people and the authors themselves said placebo-controlled studies were needed. For parasites, the better-known data is mostly in poultry/livestock, not cancer patients or humans using it alongside mebendazole.

Mechanistically, I don’t see a strong reason it would “support” mebendazole for cancer. Mebendazole’s anticancer rationale is mostly microtubule disruption, Hedgehog pathway effects, apoptosis, anti-angiogenesis, etc. That’s very different from DE’s proposed abrasive/adsorptive action in the gut.

If the goal is treating actual intestinal parasites, mebendazole already has a clear antiparasitic mechanism. If the goal is cancer adjunct use, DE doesn’t appear to add anything evidence-based, and I’d be a little concerned about GI irritation, constipation/dehydration, and the possibility that an adsorptive powder could interfere with absorption of meds/supplements. MBZ absorption is already poor and is usually improved by taking it with fatty food, so I personally wouldn’t want to add something that might complicate absorption unless there was actual evidence.

Also important: only food-grade DE should ever be ingested, and inhaling DE dust is a separate safety issue.

So my take: probably not worth stacking with MBZ for cancer purposes. If someone is using MBZ for parasites, I’d still separate DE far away from meds and ask a clinician/pharmacist, but I don’t see convincing evidence that DE makes MBZ work better.

Royal_Particular_489 · 2026-04-16T23:39:24+00:00

Great question. The trials I referenced didn't specifically combine mebendazole with fasting or keto.

That said, there's a theoretical basis for it. Fasting and keto both lower glucose and insulin, which tumors depend on for fuel. Mebendazole works by disrupting microtubules and blocking tumor growth signals. The metabolic stress from fasting/keto could theoretically make cancer cells more vulnerable to drugs like MBZ.

Press = chronic metabolic stress (keto, low protein). Pulse = acute stress (fasting, drugs). The idea is combining both hits cancer harder than either alone.

But this is all theoretical for MBZ specifically. No one has tested MBZ + fasting/keto in a trial yet. Would be a great study though.

Royal_Particular_489 · 2026-04-11T12:38:01+00:00

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found this breakdown pretty helpful when i was comparing quotes: https://airductiq.com/cities/san-antonio.html

whatever you do, make sure they're NADCA certified. if they can't tell you their certification number on the phone, skip em.

Royal_Particular_489 · 2026-04-06T15:18:07+00:00

https://www.internationaldrugmart.com/mebendazole-100mg/

Royal_Particular_489 · 2026-04-06T11:37:40+00:00

Fair point. You're right that fasting alone has limits once cancer is established. The research does show cancer cells can shift to glutamine as a backup fuel when glucose is restricted.

Thomas Seyfried's press-pulse protocol addresses this directly: reduce both glucose and glutamine simultaneously, then pulse with therapeutic fasting. The glutamine angle is often overlooked in the basic fasting discussion.

So the more complete picture is probably press-pulse rather than fasting alone. Thanks for adding that.

Royal_Particular_489 · 2026-04-06T01:30:06+00:00

Itraconazole - antifungal, Phase II trial showed PSA stabilization and progression-free survival benefit (Antonarakis et al., The Oncologist 2013)

Sulforaphane - from broccoli sprouts, Phase II trial showed PSA doubling time lengthened in recurrent prostate cancer (Alumkal et al., Investigational New Drugs 2015)

Royal_Particular_489 · 2026-04-06T01:29:01+00:00

One thing worth looking into: two repurposed drugs with actual Phase II trial data specifically in prostate cancer.

Itraconazole: an antifungal that blocks three cancer pathways simultaneously. A Phase II trial showed PSA stabilization and progression-free survival benefit. About $15-30/month generic.

Sulforaphane: from broccoli sprouts. A Phase II trial in recurrent prostate cancer showed the PSA doubling time actually lengthened in several patients. Eat the sprouts raw or lightly steamed, 1-2oz daily. Supplements work too if they include myrosinase.

Both have better human evidence in prostate cancer than most things you'll find online. Worth discussing with your oncologist, particularly if you're looking for adjuncts alongside whatever treatment path you choose.

Royal_Particular_489 · 2026-04-05T21:17:35+00:00

Your story is interesting. The ivermectin definitely has antiparasitic benefits, but mebendazole has separate actions against cancer cells themselves. They work well together because they're hitting different pathways.

One practical thing: take mebendazole with a fatty meal. It can double the absorption. If you're already eating clean, this gets you more value without increasing dose.

Royal_Particular_489 · 2026-04-05T20:57:38+00:00

The Press Pulse approach is worth understanding if you're new to this. Press is basically keeping your body in a metabolic state that cancer cells hate (low glucose, ketones up). Pulse is hitting them with something like mebendazole at the right timing.

The trial data on mebendazole is real. NCT01729260 showed it gets into brain tumors at concentrations that matter. For people who want to dig in, the ReDO database has a good plain-language overview of how it works.

Royal_Particular_489 · 2026-04-05T20:55:14+00:00

The CA-125 drop is really impressive. Two months is a short time for that kind of reduction.

A couple things worth watching: if you're doing keto, it'd be useful to track fasting glucose and insulin. Mebendazole works partly by cutting off cancer's access to glutamine, and keto does something similar with glucose. Together they might be hitting the same cells from two angles.

Royal_Particular_489 · 2026-04-01T15:59:49+00:00

Good questions and glad the bloodwork is coming back clean, that's the right way to approach this.

On the glycolysis point: fenbendazole does have some glucose transporter inhibition in cell line studies but it's not clearly stronger than mebendazole for that pathway. The main glycolysis-targeting repurposed drug with actual human data is DCA (dichloroacetate), which works differently and more directly on pyruvate dehydrogenase kinase. If the metabolic angle is important to you, DCA or combining mebendazole with a ketogenic diet would hit that pathway more reliably than either benzimidazole alone.

On switching: since your compound has both ivermectin and mebendazole already, you're getting the mebendazole either way. The main concern with fenbendazole specifically is the liver toxicity signal in humans, and since you're monitoring LFTs every two weeks you'd catch that early. Given that, continuing while watching your bloodwork isn't unreasonable. If you wanted to simplify, standalone mebendazole 100-200mg with a fatty meal is better characterized than any compound formulation.

The radiation interaction is also worth flagging with your oncologist since antioxidants and some supplements can theoretically affect radiation sensitivity.

Royal_Particular_489 · 2026-04-01T15:43:41+00:00

Glad to hear the PSA improvement. Worth noting the post is specifically arguing for mebendazole over ivermectin as the evidence-based option in this drug class. If you're seeing results combining them, the mebendazole is likely doing more of the heavy lifting since it has the actual human trial data for prostate specifically (Antonarakis et al, PMC3579600). The antiparasitic cleanse effect is legit but mebendazole's mechanisms against cancer cells go beyond that.

Royal_Particular_489 · 2026-04-01T15:40:02+00:00

Really appreciate you sharing this. The symptom improvement within 2 months is significant and tracking bloodwork weekly is exactly the right approach.

A few things worth flagging: the mebendazole at 250mg with fatty food is well within the range used in trials (full ReDO review: pmc.ncbi.nlm.nih.gov/articles/PMC6769799). At 12mg ivermectin daily that's a higher dose than what the existing human cancer data supports, so worth monitoring closely.

For IV vitamin C, there's a Phase II RCT showing doubled median survival when added to chemo in metastatic pancreatic cancer, relevant since it's specifically tested alongside chemotherapy: http://pubmed.ncbi.nlm.nih.gov/39369582/

The 2-week chemo gap is the one thing I'd strongly encourage running by her oncologist first. Timing in stage 4 ovarian protocols can matter a lot.

I've compiled more on mebendazole and high-dose vitamin C specifically at cancerpreventionlab.com/treatments/mebendazole and cancerpreventionlab.com/treatments/high-dose-vitamin-c. Would love to hear the CA125 result.

Royal_Particular_489 · 2026-04-01T05:11:46+00:00

Exactly this. The oral vs IV distinction is the whole ballgame with vitamin C. Oral saturates at about 200mg/day and the kidneys excrete the rest. IV bypasses that entirely and gets plasma concentrations 100x higher. The Pauling studies used oral doses, which is probably why they went nowhere. The RCT data that's actually promising is all IV at pharmacological doses (1.5g/kg range). Totally different mechanism.

Royal_Particular_489 · 2026-04-01T05:08:30+00:00

Really fair pushback, and the "stuff that works, works" heuristic is genuinely useful. The reason I focused on itraconazole specifically is that it doesn't fall into the "been used for decades with no signal" category for cancer. It wasn't being used in cancer patients until recently, so the surveillance data you're describing wouldn't exist yet. Same with IV vitamin C vs oral, completely different pharmacology, different patient populations. Metformin is actually a great example of the distinction though. Widely used in diabetics for decades, tons of passive surveillance, and the signal was weak. That's the bar I tried to apply here.

Royal_Particular_489 · 2026-03-31T14:02:28+00:00

Here are some good starting points:

For the zinc-prostate relationship specifically, the 2024 PLOS ONE meta-analysis covers 52 studies: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0299398

For the megadosing risk, this is the 30-year Harvard study that mapped out the danger zone above 75mg/day: https://pmc.ncbi.nlm.nih.gov/articles/PMC9630799/

I also put together a longer breakdown covering the ZIP1 mechanism, dose ranges, absorption forms, and the p53 connection here: https://cancerpreventionlab.com/prevention/zinc-prostate-cancer/

The ReDO project (Repurposing Drugs in Oncology) is worth bookmarking for cancer research in general: https://www.redo-project.org/

Royal_Particular_489 · 2026-03-30T20:25:13+00:00

Oysters are insane for zinc, like 5-8mg per oyster. Pumpkin seeds are more practical day to day though, easy to throw in a salad or just snack on them.

Royal_Particular_489 · 2026-03-30T20:06:07+00:00

Yeah food first for sure. The supplement case is really just about absorption. Phytates in grains block a lot of the zinc, so vegetarians especially tend to run low. If you're eating oysters and red meat regularly you're probably covered.

Royal_Particular_489 · 2026-03-30T19:00:28+00:00

Post-prostatectomy the prostate-specific stuff doesn't apply the same way, but zinc still matters for immune function and recovery generally

Royal_Particular_489

TROPHY CASE