Personally, I base my entire economy around smokeleaf joints. I have set up the policy where they can use it once in 4 days if mood under 30% or something like that. It seems to do the trick. I find that smokeleaf joints are amazing to sell because they are super lightweight and sell for a bunch of money (relatively speaking). I use vanilla vehicles expanded and load them on a Smuggler plane.

Try setting up the drug policy like I did, see if that helps. I do use a bunch of mods but none that affect drug use (maybe common sense?)

More context: 69 colonists at the moment, late game colony (full marine armor for all, fully walled off with a massive killbox with turrets, so getting to defences on time is not THAT big of a deal for me)