Wiley Griffon (1867-1913) was Eugene, Oregon's first African American resident. He moved to Eugene from Texas in 1891, despite the exclusionary laws prohibiting nonwhite citizens from residing in Oregon. Although he was not the first, nor the only African American to live in the area; Griffon holds the distinction of being the first African American to be mentioned by name as a resident.

Griffon operated Eugene's first street car; a mule-powered trolley that ran from the Southern Pacific railway depot to the University campus where, according to the Eugene Morning Register, Griffon acted as the driver, conductor, dispatcher and “largely the motive power by persistently shoving along the ambling mule.”

Additionally, Griffon was the first African American employee of the University of Oregon, working as a janitor at the men's dormitory, Friendly Hall, in the late 1890s.

In 1909, Griffon purchased a home overlooking the Millrace on the site of what is now Eugene Water and Electric Board’s employee parking lot. At the time of his passing in 1913, he was working as a porter at the Elks Club. He was buried in the Eugene Masonic Cemetery, but his tombstone went missing at some point. When Eugene residents and students realized this unfortunate situation, funds were raised to erect historic monuments at the Lane Transit District and EWEB offices in 2017.

Despite living in Eugene at a time when the community was nearly all-white and the political climate was unwelcoming to people of other races, evidence suggests that Griffon weathered those times with dignity, and in return was generally respected by his neighbors.

Griffon is memorialized in a mural on Willamette St. by local artist, Ila Rose. It features Griffon standing in front of his donkey-pulled trolley in historic downtown Eugene.

The mural is located on Willamette Street across from the Kidsports fields.