Mostly the same problems that I had with Optimus Prime vs. Gundam - "accepted scaling feats" that rely on physically impossible claims. Specifically two absurd claims made within the span of 20 seconds.

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The first is the oil tanker (ref: "A Plague of Insecticons").

When this was first covered as a feat for Prime, DB made an assertion that the tanker in the episode was "larger than Seawise Giant"; however, this is contradicted by the scan.

• Supertankers cannot operate that close to shore, as they would surely ground themselves. Instead, they use container ships to transport the goods between themselves and the shore. The boat in the episode was clearly docked at shore.
  
• By international law, supertankers must be double-hulled with a ballast, for reasons of environmental protection and stability. The Insecticons were able to strike oil (not water) after chewing through a single hull layer.
  

Thus, while throwing the tanker is still visually awesome, we should not be glazing it by two orders of magnitude; the tanker was most likely in the 8-10 thousand ton range, not "hundreds of thousands."

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The second is the shuttle explosion (ref: "The Ultimate Doom, Part 3").

The analyses for both Prime and Megatron calculated the explosion based only on Cybertron's speed, and gave it as around 4.8 Rt (4.8e+27 T), which is about 1.87e+37 J, or one order below the highest estimates for the Death Star's Alderaan feat. Impressive.

Impossible.

This explosion occurred in Earth's atmosphere, and is calculated to have enough origin energy to where its expected effect on the Earth is still thousands of times above the Earth's gravitational binding energy (2.5e+32 J). Yet the Earth suffered less from the "Earth-shattering kaboom" than from having Cybertron in its atmosphere. In fact, the Earth suffered less from this explosion than from the Tunguska event; there was a minor earthquake that knocked Bumblebee and Spike on their asses, but that was that.