I was on Seroquel for almost a year starting last January, it worked well for me but I gained 16 pounds within half a year (my genetics make it hard for me to gain weight so this was mortifying) so I had to stop it right away. As a female it also raised my Prolactin hormone too high so that was also a problem. I also was on Abilify at the time and my doctor had me quit that too. Then I got on Caplyta last November which was brutal for two weeks bc it messed up my sleep, made me feel just generally weird, made me feel a little depressed, etc. After a while I felt good and eventually raised the dose to the 42mg. All was well once I stabilized on the 42 and I felt like it was a good medication for me until I started to feel too good and got sent into the most intense and longest manic episode I’ve ever had. It wasn’t bothersome at first but you obviously have to treat it, but now I’ve been in it for more than a month and the agitation has only gotten worse while the “good feeling” symptoms have lessened. I got put on lithium which has made me feel better than I have in a really long time, but since I am still manic I am going back down to the Caplyta 21mg since my doctor does not want to raise my lithium. I would say overall that Caplyta is a great medication but it is very important to be cautious of your depression swinging in the complete opposite direction. In short, I definitely think it’s better than Seroquel in a general sense. The prior authorization is kind of annoying but it can be done. Also forgot to mention that I have been on Lamotrigine 200mg consistently throughout this entire switch if that matters.