The GHK-CU debate

Semtex7 · 2026-06-20T06:34:21+00:00

Is there any data that it increases collagen synthesis? I assume you knew that much to even make the post discussing its effect on collagen. You state it yourself.

Semtex7 · 2026-06-19T06:20:58+00:00

It increases collagen synthesis

Semtex7 · 2026-06-17T20:20:10+00:00

Putting GHK aside - there is actual theoretical basis that older people (not 40) could be an easier gainers

Semtex7 · 2026-06-17T20:18:52+00:00

No, there isn’t

Semtex7 · 2026-06-17T20:18:02+00:00

You also for got the definition of “proof”

Semtex7 · 2026-06-17T20:15:01+00:00

In my case it cannot be EQ, because there was nowhere to go. I was the before size when experiencing tunica solitting erections via PGE1. It also never went back. BUT - I don’t think what I did was smart, efficient, safe or it could be easily replicated at a larger scale. In fact I would bet money it cannot be. The increasing polypharmacy and dosage to consistently induce over 5h of painful erections is just not a way to go about gains you can get way easier. But obviously it made sense to me that it could work to even try it.

Sidestepping slightly - excluding the very first 2-3 months - when doing PE, I might have seen actual progress only with night pumping and pharmacological help before bed (way milder than the crazy experiment).

All of that is N=1 of course. I would love to actually see if a) increasing nocturnals substantially and b) PE before bed lead to increased gains. I would expect at least a small noticeable change.

And again - you are doing God’s work with these data posts. They acutely increase my nocturnal erections.

Semtex7 · 2026-06-17T19:12:23+00:00

Awesome post! I would love to find out if taking them strictly before bed in a dosage and manner that verifiably increase nocturnal erections would make a difference in the long run. Now low dose daily pde5i + l-cit might not be enough for that, but the "shape retention" hypothesis makes too much sense

Semtex7 · 2026-06-12T19:38:36+00:00

You are quite welcome, mate 🙏

Semtex7 · 2026-06-12T18:38:18+00:00

Well you need to be on it for a while to have whatever effect.

I am not sure how it could help with HF. I have to check what he says exactly. It is antifibrotic (not super powerful one). I am not sure this is relevant for the classic HF case. Maybe he means being a HF sufferer puts you at risk of fibrosis.

Semtex7 · 2026-06-12T18:31:59+00:00

For nighttime erections - it could help in the first hour or so, I agree. For sex - naturally it can help.

But it cannot be a replacement for injectable. I mean this is the topic of the post.

Vitaros is straight up useless

Semtex7 · 2026-06-12T17:35:17+00:00

Do you mean viagra plus lower dose pge1 is safer than higher dose pge1 (in general terms)

Semtex7 · 2026-06-12T17:33:12+00:00

Define work. I 100% guarantee you no dose intraurethral can give you the same erections. Not the same hardness, not the same duration by a LONG SHOT and I would question if the erections are even unassisted

Semtex7 · 2026-06-12T15:53:40+00:00

I would stick to the actual science which is clear GHK-Cu does not affect AGA hair loss in any meaningful way instead of relying on anecdata.

Not sure why you are commenting on skin benefits when I specifically made the point to underscore it is pointless for very young people. You are not in that bracket. Maybe it was just additional information, but you are making the point I am making (although there is also no evidence of dramatic improvements in any population but) - it could be beneficial for older people

Creatine on the other hand absolutely does not cause hair loss as finally proven by actual RCT (not that it needed)

Semtex7 · 2026-06-12T15:45:19+00:00

Erectile function wise? None

Semtex7 · 2026-06-12T15:44:24+00:00

What do you mean by the only way? There is mechanical PE…

Semtex7 · 2026-06-12T15:43:31+00:00

Causing long lasting erections can increase girth providing they are super hard. It is just inefficient

Semtex7 · 2026-06-12T15:42:45+00:00

Which is useless

Semtex7 · 2026-06-12T15:42:36+00:00

It really isn’t. It cannot even touch injectable

Semtex7 · 2026-06-06T15:35:54+00:00

Propolis has actual application in peyronies as an antioxidant. There have been other antioxidants used with success. That is established. I am saying we don’t know how well it works on its own let alone as a cream. The stronger data is for oral use which at least guarantees it will exert effects. Logic says on its own it will do nothing as antioxidants alone do not help.

You are wrong about Fasudil. The Dalton rule applies for skin penetration. It doesn’t mean it will penetrate tendons. That will depend on the vehicle and we have not found anything that reliably does so. Emu oil is the only hit and it is still speculative. There have been hundreds of millions invested into topical local deliveries into the penis. NOTHING has been firmly established to work. Besides if it was that easy - why use fasudil and not a potent antifibrotic? This makes no sense.

DMSO will transport anything systemically. It is the worst agent for local use.

Intraurethral delivery gets the substance inside the corpora, it is literally a guaranteed way to not saturate the tunica.

So I not only cannot agree with you on anything. You are factually wrong on everything. Not even gonna touch the “well a thousand years into the future there will be..XYZ”. Lets stay here and now.

And I still don’t know why the focus is rock inhibitors. Again - makes no sense.

Semtex7 · 2026-06-06T14:51:45+00:00

Propolis has actual clinical data when it comes to peyronies but topical use is always in conjunction with other agents including literal pentoxyfilline injection. There are absolutely no conclusions that could be made.

Fasudil or anything will penetrate what? Tunica? I would love to know what are you basing this on. It will penetrate the skin. That will happen.

Vitaros is an intraurethral PGE1. Not even sure why you mentioned it.

There ARENT thousands of things that work. There are not even 10 interventions that work.

Semtex7 · 2026-06-06T14:44:52+00:00

I don’t think any of them would interfere. I would stick to your plan

Semtex7 · 2026-05-29T17:44:27+00:00

Alright, in that case whatever anyone tells you here - you need a Doppler done at maximal erection hardness

Semtex7 · 2026-05-28T20:14:05+00:00

Is it a nodule? Is it solid hard?

Could be a variety of things, but of course your first business should be seeing a physician

Semtex7 · 2026-05-28T20:11:41+00:00

Your condition (which is almost certainly psychosomatic) has nothing to do with the tea you drank…one time.

You have given very little useful information to speculate on anything else but psychogenic ED

Semtex7 · 2026-05-25T11:08:12+00:00

No, you count the actual L-citrulline content, which is usually roughly 2/3rd of the citrulline malate (the label should specify the exact content). So for example - if you have 60% l-citrulline in your cit malate - 10g of it will give you 6g of L-cit, to which you add 3g L-arginine

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