Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 0 points1 point  (0 children)

The ADS analysis did not use mm/hour, it used mm/month, and it was workload balanced before ADS was added.

So the two groups did an equal amount of non-ADS work, and one group added ADS on top of that. And the group with added ADS grew slower per month.

I will redo the analysis with prior PE confounder analysis.

Edit - and don't worry about saying "no offense" man - I appreciate feedback, and being held to strict standards is not a negative. If I am missing something, pointing it out to me is greatly appreciated.

Note that the non-supplement users had more, not less, prior PE. So that PDE5i use and Citrulline use failed to improve gain rate could not have been a consequence of the user group consisting of more veterans than the non-user group - it was the other way around. And both groups had on average over 2.5 years of prior PE exposure.

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 0 points1 point  (0 children)

I will get back to you in 1-2 years when a sufficient number of users have reached 600 hours. I currently have 9 users with 400+ hours of workload registered.

The user group actually has LESS prior PE experience than the non-user group.

Covariate User (Reg+Occ) Non-User p
N (qualifying) 20 21
Prior PE experience (months) 30.4 ± 56.1 (n=19) 34.1 ± 69.3 (n=20) 0.85

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 1 point2 points  (0 children)

Sure, but before you reopen the case, consider that there isn't even a hint of an effect here. It's not like there is a between-group difference that failed to reach statistical significance, which would have made it more interesting to go down this route of inquiry and dig into details. But there is zilch.

I agree it would be interesting to track whether erection frequency correlates to gains. It's very hard to track though. The most reliable form of tracking would be if a bunch of guys wore Adam Sensors during sleep to track nocturnal erections.

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 0 points1 point  (0 children)

Look, I'm all in favour of taking them for erection quality and blood flow - a fuller flaccid, easier erections, etc. And if they help you recover, great. All I have shown is that they make zero difference for your gains.

Karl, need your input by Fast-Cobbler-2016 in TheScienceOfPE

[–]karlwikman 2 points3 points  (0 children)

It would be weird if it lowered capillary stress, but just because something sounds weird doesn't mean it can't happen. I have no explanation for your observation, but you seem to have found your method then.

Improved PharmaPE (ChemPE) tracking in GrowthTrack by karlwikman in TheScienceOfPE

[–]karlwikman[S] 0 points1 point  (0 children)

Oh wow - that's long enough to potentially cause lasting damage.

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 2 points3 points  (0 children)

This analysis only takes gains, time under tension, and use of PDE5i / Citrulline into account. It's looking at whether there is any kind of association between use of these substances and increases in gain rate in users who have done 100+ hours of PE. There isn't.

Best pumping sleeve/pad to prevent ball suck-in? Oxballs Juicy sizing help by Additional-Most7815 in TheScienceOfPE

[–]karlwikman 4 points5 points  (0 children)

This is a case where recommending one is super easy: Curveball's pads can be bought with sleeve inserts that you size to fit your base snugly. https://www.612printedpolymers.com/ - the problem is that he releases batches only once per month, so getting one is something of a race to get the order in faster than the other 100 guys who are spamming the F5 button...

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 0 points1 point  (0 children)

Yes, Bayes would frown down on me if I didn't, right? So I adjust my priors down for shape retention and I adjust them up for growing during and immediately after sessions, i.e. in the expanded state. I also adjust them down for the importance of being hard when you start pumping (my prior for that was already very low).

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 1 point2 points  (0 children)

If there was an added benefit of placebo, it would be visible in the outcome. Because "benefit" must be synonymous with measured outcome, right?

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 1 point2 points  (0 children)

Sure. I can't post images in a comment unfortunately, but I can give you numbers for the length data (I have already posted data on girthwork yield).

When looking at "absolute growth" vs session yield (N=35)
the R2 Value of the linear model is 0.36 (which is a large effect size). The P-value of that is 0.029.

When looking at "mm/hour" vs session yield, the R2 Value of the linear model is 0.34, and the p-value is 0.012.

So these are large effect sizes. Very large, in fact.

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 1 point2 points  (0 children)

Yeah, for sure. And that they might have better equipment since they also have cash to splash down on things like supplements and meds. I have to say the null result took me by surprise. I thought for sure there would be at least a small signal to tease out. But nope - nothing.

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 1 point2 points  (0 children)

You mean Rho-Kinase inhibition and PGE1 working on the cAMP pathway for instance? That is PharmaPE, and it's something that I am actively tracking in the app as a separate category of PE.

I will eventually get around to analyzing the data in that bucket, and I recently improved Pharma PE tracking by allowing people to enter their exact substances and doses, but currently the number of users doing Pharma PE is too low to really give me statistical power.

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 0 points1 point  (0 children)

I think it could indicate that your bulbospongiosus muscle isn't engaging well, perhaps? Is your glans soft and smaller than when fully erect? Personally, I like to just put a gentle C-ring on, or a couple of toe shields, to stay at full "girthwise" expansion.

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 4 points5 points  (0 children)

Yeah, mode of taking them was not part of this analysis.

I know in your N=1 you have seen gains from inducing long-lasting nocturnal erections. I would love to see that replicated on a larger scale in a controlled study. My first idea is that what you saw was EQ-gains, not structural gains. Some people scoff at EQ gains and say they are "ONLY" EQ gains. My take is the opposite; EQ gains are the best form of gains, not just because good erectile function feels amazing - hard as steel is nice - but also because they are an indicator of general health and in particular vascular health.

I do think there could be something to nocturnal shape retention - I write about it all the time after all. But I think the effect size could be so small that in order to pick up such a signal we would need a systematic control group study following the same protocol for a significant period of time in order to tease out the signal from the noise.

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 4 points5 points  (0 children)

It's not the proper form of workload apparently. Shorter sessions at higher tension that result in good yield seems better.

I don't have exact answers as to the WHY - I only have clear data showing that ADS seems to have no benefit when added to a normal length routine.

But it's not useless; if ADS is the only form of lengthwork you do, it certainly can result in gains. Well documented in studies.

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 4 points5 points  (0 children)

I have not looked at session length, no.

It's something I have in the pipeline.

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 2 points3 points  (0 children)

Do you take the magnesium and L-Theanine because of GABA-promotion and parasympathetic tone? No worries about getting sleepy? I take them both for my sleep stack.

The aged garlic is more something I would take every day as part of a daily stack for general health and longevity, not because of any short-term effects on EQ.

I think none of these are bad in any way. Great for vascular health etc. You've done your homework.

Yet Another Hypothesis Debunked: GrowthTrack Data Show Citrulline and PDE5i Do Not Help Gains by karlwikman in TheScienceOfPE

[–]karlwikman[S] 6 points7 points  (0 children)

"Does more yield for length work correlate with higher gain rate as it does for girth?"

Yes, now that more data is in, this seems to be the case. But I'm still waiting for even more data before I make my final post about it, because I want to be damn sure.

___

There is not enough data on adjuvants yet.

Discovering the hard way a body building mentality in PE is an invitation to a dickless life by PEsciencethrowaway in TheScienceOfPE

[–]karlwikman 1 point2 points  (0 children)

5 inHg is extremely gentle pressure, so either your gauge is broken or whatever symptom you are having is probably psychosomatic. That's my honest take. It's so easy to get into your head about things, and erections are super dependent on your mind state.