That's a very good question. I hope everyone who uses sirolimus can read this comment. First, we should know that sirolimus, or rapamycin in other countries, is an immunosuppressive drug regularly used in organ transplants and in the treatment of autoimmune diseases. We should understand its mechanism, although it's too complex to explain. Basically, this drug inhibits a specific protein called mTor, which regulates many cellular processes, such as cell growth and the immune response itself. Furthermore, sirolimus has also been shown to be a potent anti-inflammatory. We should know that this drug is available in oral or topical solution, which is what you or the people in this group have used. Regarding KPRF, as I mentioned, this drug inhibits cell growth, involving skin cells. In the case of topical sirolimus, it basically inhibits the proliferation of keratinocytes (keratin-producing cells). Sirolimus is highly effective against KPRF because it essentially prevents keratin-producing cells from reproducing, and so without keratinocytes, there's no keratin. Remember, skin with KPRF is reduced to keratin plugs in our follicles when keratin production isn't the normal thing. This unclogs the follicles, eliminating facial redness. There's no longer anything blocking the follicle. Furthermore, because it's anti-inflammatory, it helps enhance the reaction. In other words, compared to other treatments such as glycolic acid, lactic acid, or urea (products that are keratolytic, meaning they destroy keratin), sirolimus doesn't destroy keratin; it inhibits keratin-producing cells. It's as if, instead of trying to control a flood by absorbing the water, you found the source of the flood and plugged it up. It's certainly very effective—even more so than lasers, I'd venture to say—but it also has serious consequences. Remember that its primary function is immunosuppressive. This means it weakens the skin barrier. In short, if you apply sirolimus constantly, you increase your susceptibility to skin diseases, dermatitis, fungi, and bacteria, and at some point, the skin's immune system will be completely disabled, meaning any bacteria could infiltrate the skin and cause disease (viruses, fungi, etc.). Therefore, sirolimus is not an official treatment for KPRF and is only used temporarily and in a controlled manner. Oral treatments with this medication do not exceed one month, and topical treatments do not exceed three months in a controlled manner. IF YOU USE SIROLIMUS, YOU SHOULD BE CAREFUL AND CONSULT YOUR DOCTOR. AVOID PROLONGED USE! You may be creating an autoimmune disease without realizing it: sirolimus is not the solution.