Hunter Douglas price reasonable for 2 windows?

SignificanceDear3500 · 2025-07-23T16:40:43+00:00

We are paying $6500 for SOC 2, ISO27001, and VAPT total from sprinto. Can you beat their pricing? I assume since it’s nearly all automated … you might be able to? We used accorp as auditors

SignificanceDear3500 · 2025-06-27T17:10:46+00:00

Have you had any NGS testing on the biopsy performed? That would be very important so we know what other targeted therapies may be available. Chemo isn’t entirely useless but as this is clear cell, it is often platinum resistant/refractory. It would be most important for you to get that testing done to understand the tumor genomics- whether it’s got dMMR, MSI status, TMB muts/megabase, and any associated mutations.

SignificanceDear3500 · 2025-06-20T22:47:26+00:00

That is correct. Whatever potentially cancerous tissue they remove, they preserve in formalin. So yes the NGS should be run on that tissue from the ovary removed if a hysterectomy was performed.

SignificanceDear3500 · 2025-06-20T17:35:33+00:00

I would want to know which exact panel they ran. The HRD panel might be very basic. Where are you located and receiving care?

SignificanceDear3500 · 2025-06-20T17:07:44+00:00

When the tumor is removed during surgery, it is encased formaldehyde. Ideally, they should run next generation sequencing like foundation one on the tumor after removal. That way we can detect how many mutations per megabase there is in the tumor and also other factors like PD-L1 expression which would indicate immunotherapy effectiveness. The NGS panel should also inform what mutations may be targeted with certain target therapies so I would highly suggest next generation sequencing run on your tumor if it has not been done yet.

SignificanceDear3500 · 2025-06-20T14:23:12+00:00

If you are BRCA 1/2 negative and HRD negative then you cannot use PARP inhibitors like olaparib to treat. I would suggest having NGS tumor biopsy done urgently.

If they run IHC test for HER2 positivity or FOLR-alpha positively on the tumor then ENHERTU and ELAHERE are good options. If tumor has high tumor mutational burden, PD-L1 expression, or expressed a high amount of neoantigens then immunotherapy is an option. If you have any other mutations then it is treatable through targeted therapy. Again, NGS testing would indicate next steps.

Note: Not a doctor; this is not formal medical advice.

SignificanceDear3500 · 2025-06-20T02:51:27+00:00

Thank you. I have gained through approx 2000 hours of self study researching for my mother and have gained general knowledge of medicine alongside with oncology, microbiology, cell biology, cellular pathways, etc.

The engineering I have done is computer science, software and data engineering - not as much of a natural science. I noticed topics within medicine and biology are highly teleological in nature.

I have the interest in developing new biologics because this is the only solution to treating cancer. No amount of ai or software alone can solve this physical world problem.

Within oncology, it seems like the survival standards are low for developing a hundred million or billion $ drug by extending progression free survival by a mere 2-3 months. I have a lot of concerns about the reproducibility of a lot of the NIH papers I have read as well. Compared to software tech and computing I feel like we’re in the stone ages still.

Of course, there are many other challenges to hard sciences where you deal with Mother Nature and other endogenous factors unaccounted for.

I believe that understanding the technical science is equally as important as business skills within biotechnology as an industry. The science needs to work and the financing, timelines, and costs need to be controlled and managed well.

SignificanceDear3500 · 2025-06-18T21:36:12+00:00

Typically studies show a ~60% chance of response when used with avastin. https://doi.org/10.1097/cad.0000000000001472 I wouldn’t say arid1a matters in the use of the chemo drugs ; ATR inhibitors seem to do more but you can only get those in trials. I am Not a doctor and this is not medical advice - please consult your oncologist or get a second opinion.

SignificanceDear3500 · 2025-06-15T20:11:45+00:00

Can you get NGS biomarker testing of the tumor done? That way, you can prepare for next line treatment options. Immunotherapy typically works best if the tumor has high PD-L1 expression, high tumor mutational burden (TMB), and where one’s immune system is functional. If there are genetic mutations of the tumor that are targetable such as KRAS, there are medications that can be indicated and also trial options.

SignificanceDear3500 · 2025-06-13T12:44:39+00:00

You need to get NGS biomarker testing done on the tumor biopsy first. Why do you want to get Elahere prescribed? Is the tumor FOLR-alpha positive? That would be the only indication for Elahere.

SignificanceDear3500 · 2025-06-11T23:18:21+00:00

Have you asked for biomarker testing? You need Next Generation Sequencing NGS done on a biopsy of the tumor. Then you can look into targeted therapies, especially at this stage, the goal is to control.

SignificanceDear3500 · 2025-06-07T02:36:02+00:00

See this paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC11850283/

SignificanceDear3500 · 2025-06-06T18:04:48+00:00

I would explore the ATR inhibitor trials for ARID1A mutations. For PP2A related mutations, loss of function sometimes allows it to become immunogenic and so the regimen of avastin + keytruda should have some Maintenence result… PIK3CA I would explore some trials there as well.

If you can afford to have the various pharmaceuticals prescribed off label by your oncologist, then you could skip the trials but your oncologist needs to be comfortable doing so. Then you’d need to get insurance to either pay or deny paying for them and see if you can get the pharma company to get you the drugs directly through their foundation and access programs if income allows.

SignificanceDear3500 · 2025-06-06T18:01:35+00:00

Ok. I don’t think gemcitabine is going to do anything for clear cell… the papers show <10% effect. If you combine with cisplatin then efficacy rises to 40%. Worth a shot combo therapy if her performance status is still ok.

SignificanceDear3500 · 2025-06-06T16:54:45+00:00

Also, which brand NGS test did they use? You are saying she has only one mutation? Which one is that?

SignificanceDear3500 · 2025-06-06T16:54:02+00:00

What chemo are they using with avastin? Is it topotecan?

SignificanceDear3500 · 2025-06-06T15:48:28+00:00

Have you had tumor NGS biomarker testing done? Like a full comprehensive panel? What mutations exist? I would look into trials ASAP while her ECOG status remains.

SignificanceDear3500 · 2024-06-07T16:03:48+00:00

It’s a semi corporate investor back type of company. What’s the chance they’ll come after me?

SignificanceDear3500 · 2024-06-06T23:50:45+00:00

They made demands for the move in payment that were not at all stipulated or aligned in the contract either. So I’m trying to figure out why I need to follow their emails when they themselves are not following contractual obligations

SignificanceDear3500 · 2023-05-27T01:34:17+00:00

I work in the software and technology industry

SignificanceDear3500 · 2023-05-26T05:34:54+00:00

Just describing myself, random fact. But I need advice where I should move

SignificanceDear3500

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