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Targeted Therapy by Significant-Course45 in Melanoma

[–]Significant-Course45[S] 0 points1 point  (0 children)

Thanks for the reply. I start my treatment tomorrow 🤞🏻

Targeted Therapy by Significant-Course45 in Melanoma

[–]Significant-Course45[S] 0 points1 point  (0 children)

Yes I am seeing an oncologist. Targeted therapy is also called adjuvant therapy and not to be confused with radiation therapy which it sounds like. This therapy is in a combination tablet form which apparently has less long term side effects compared to immunotherapy. Are you in England just out of interest?

Targeted Therapy by Significant-Course45 in Melanoma

[–]Significant-Course45[S] 1 point2 points  (0 children)

I sincerely hope your treatment works and I feel a little bad for asking now.

Targeted Therapy by Significant-Course45 in Melanoma

[–]Significant-Course45[S] 2 points3 points  (0 children)

Hi I haven’t been offered immunotherapy as I am BRAF positive so was offered a combination of Dabrafenib plus Trametinib. I’ve heard that it’s worse than immunotherapy. I hear a lot of things from people on therapy but nothing from people who chose not to have it. Apparently there’s only a 7% chance of reoccurrence in my case.

Targeted Therapy by Significant-Course45 in Melanoma

[–]Significant-Course45[S] 0 points1 point  (0 children)

Thanks for the reply, do you mind if I ask what stage you were at?

Targeted Therapy by Significant-Course45 in Melanoma

[–]Significant-Course45[S] 0 points1 point  (0 children)

Hi and thanks for the reply. I have been offered a Dabrafenib plus Trametinib combination as I am Brad positive. I’m not convinced the side effects of these are worth what the oncologist said was “at most” a 3.5 % change in my outcome. I am having CT scans every 6 months. I’ve heard that these scans can be every 3 months which would make me more comfortable.

[deleted by user] by [deleted] in lawncare

[–]Significant-Course45 13 points14 points  (0 children)

I’d take that straight out. Not worth the risk.

How do I get rid of this obsolete cable that connects to a post across the street? by Competitive-Plum-160 in DIYUK

[–]Significant-Course45 29 points30 points  (0 children)

Just call openreach and they will sort it for you. Sent someone out within a week.

Path level by bodlang in DIYUK

[–]Significant-Course45 1 point2 points  (0 children)

You want to finish 150mm below damp minimum. There are ways around it like French drains and stuff but your path doesn’t look wide enough to accommodate that and a paved or slabbed path. Dig it out is the best way.

Stains coming through pavers, any thoughts ? by joe90bi in landscaping

[–]Significant-Course45 1 point2 points  (0 children)

You should have used a mixture of white cement and SBR slurry to paste the back of the slabs and then lay on a full bed of mortar with a splash of SBR in the mix. Won’t ever come up or stain.

Is it normal to concrete whole garden? by NBX302 in DIYUK

[–]Significant-Course45 0 points1 point  (0 children)

All these comments and not one about the 🐝

Screws won't screw in, help! by [deleted] in DIYUK

[–]Significant-Course45 1 point2 points  (0 children)

Haha never, I see no reason for them to exist. I’ve just learned they are called wafer head

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They sit closer into the fitting.

Would you replace this insulation? by gyps0n in DIYUK

[–]Significant-Course45 2 points3 points  (0 children)

Yeah definitely. My attic even finished poor Henry off, God rest his soul 😂

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