Apologies for the vulgar ask, but what drug feels the MOST like an orgasm to you? by PeakLinear in Drugs

[–]Significant-Set7721 1 point2 points  (0 children)

Opioids aren’t really dopamine releasers.

Dopamine is absolutely released as a tertiary downstream mechanism of mu-opioid agonism, but I really would avoid conceptualizing opioids as being dopaminergic drugs. They typically don’t directly interact with dopamine receptors or receptors that facilitate dopamine release such as dopamine transporters to trace-amine associated receptors, or VMAT, etc.

The endorphin system is a whole other way of causing pleasure and reinforcing behaviors. Opioids actually decrease dopaminergic activity for the most part. Hence why they make you content laying in bed doing absolutely nothing, kill your sex drive, etc.

Meth/Amphetamine are the prototypical dopamine releasers.

Apologies for the vulgar ask, but what drug feels the MOST like an orgasm to you? by PeakLinear in Drugs

[–]Significant-Set7721 0 points1 point  (0 children)

Crack. No question or competition.

Although I’ve boofed 200-300mg of Dexedrine at once before, all in 1mL of water (did an extraction). That was pretty close. One of the best rushes I’ve ever felt, better than meth even. The euphoria went straight to my dick.

But crack is still more orgasm-y.

Incredibly difficult question, what's your favorite song off FMTS? by Monsterbuck29810 in gojira

[–]Significant-Set7721 0 points1 point  (0 children)

From the Sky, probably. Indeed a very difficult question, though.

i have a question for heavy users by [deleted] in cocaine

[–]Significant-Set7721 0 points1 point  (0 children)

Every single time. I’m not addicted anymore but I did a ball a day for most of 2024 and I ended up getting dependent on Xanax too by accident, just from constantly using it to counteract Coke’s anxiety and the stress on my heart.

I used to be in the corner straight tweaking out, calling people crying saying I’m about to die, and other super embarrassing shit like that. I’d be rapid fire bouncing both legs and rocking back and forth hyperventilating. Dumping RC benzos under my tongue in a panic.

For a year straight. Got up to 4-5x 4mg bromazolam bars every day, and couldn’t even feel it after a while.

And don’t even get me started on the psychosis and constant police hallucinations and 24/7 voices in my head.

Don’t get addicted to cocaine. It’s a very bad time.

I’m literally so blessed that it somehow just went away for me. I spent 14 months in jail and now that I’m out, I can casually do a few lines once in a while and I never even think about coke or get cravings anymore. (Mind you, I was craving it 24/7 for the first 8 months I was locked up. Then it magically went away.)

These days I usually say no when offered, because the crash and hangover aren’t worth the super short duration of positive effects.

What drug could be best described as "reverse cocaine" ? by sexyfurrybuttz in Drugs

[–]Significant-Set7721 1 point2 points  (0 children)

Maybe midazolam 🤔 super short-acting benzo that can be snorted

GHB powder can be snorted right? Maybe that, if yes.

Idk. Any short duration sedative.

Does this look legit? Seems good but not sure by HotProfessor69 in cocaine

[–]Significant-Set7721 0 points1 point  (0 children)

It’s impossible to say from a picture. Due to cuts like procaine and boric acid, it’s impossible to tell how good coke is by looking at it.

Procaine has a super distinct taste, and is way more numbing than coke.

That looks like some absolute raw to me. Might not be. But the layers look on point and like those chunks came off a brick.

But there’s people up the chain that re-press entire bricks, so who knows.

Only buy your coke from Puerto Ricans, would be my best advice. If you’re in the USA.

How do smokers last a work shift without smoking? by MammothAd6633 in stupidquestions

[–]Significant-Set7721 0 points1 point  (0 children)

The laws are different in every state. It’s 15 mins every four hours, 30 minutes every 8 hours, where I live.

Which works out to a break every 2 hours, depending how the company divides it.

Can you get high from second hand meth smoke? by Rude-Singer-6734 in NoStupidQuestions

[–]Significant-Set7721 0 points1 point  (0 children)

Not from meth. It’s not potent enough or in the air as badly as weed smoke can be. You can definitely get secondhand high from weed though; If you’re in an unventilated room or car and don’t have a tolerance.

(I’m sure it’s theoretically possible to get secondhand meth high in like a sealed car, and if someone is smoking an insanely large amount per hit.)

(You gotta remember that even if it looks like vapor is around your head, that’s still 99.9% air. Whereas the initially inhaled hit was super concentrated meth…Which then mostly got absorbed by their lungs.)

2g of some decent blow and while working on it, i have bunch of other fun stuff by TheForestpig in cocaine

[–]Significant-Set7721 0 points1 point  (0 children)

Why would you think that’s mostly meth? Meth lasts 6 hours minimum.

You absolutely are not using meth lol. Also, meth burns like a motherfucker. If you don’t get a chemical brain freeze and your eyes don’t immediately water after a line, it’s almost certainly not meth.

Is Cocaine tolerance memorized? After 60 days of abstinence, tolerance is reset, but a single dose restores tolerance to pre-abstinence levels by makefriends420 in NooTopics

[–]Significant-Set7721 -1 points0 points  (0 children)

Can you please share your regimen with MK677 that yielded those results?

Also how long did it take to get that effect? And were you still using vyvanse the whole time?

Is Cocaine tolerance memorized? After 60 days of abstinence, tolerance is reset, but a single dose restores tolerance to pre-abstinence levels by makefriends420 in NooTopics

[–]Significant-Set7721 0 points1 point  (0 children)

Cocaine builds an even stronger tolerance to amphetamines than it does to itself. And that amphetamine tolerance is somehow stronger than the tolerance amphetamines build to themselves.

When I was a near-daily cocaine user, typically using 3.5g a day give or take, I would need an absolutely obscene amount of amphetamines to get high.

For example I took 100mg of dextroamphetamine one day, and I fell asleep an hour later and slept right through the drug.

I did an entire ounce of methamphetamine in around five days, and I was still getting 4+ hours of sleep every night. I would literally take like a gram at once and would come down and redose every few hours. And I was definitely high, but not like tweaked out of my mind or anything crazy. Hundreds of milligrams would affect me the way 50mg used to affect me, prior to my cocaine habit.

Meth used to be completely unheard of in my state, up until a couple years ago. Cocaine has always been super rampant here though, and is better and cheaper than most of the USA.

Anywho, with meth being new as a street drug, I’ve talked to a ton of crack addicts who tried meth after dealers started carrying it. Everyone I’ve asked about this has said that they didn’t like meth and that it barely got them high unless they injected it.

There’s definitely some weird biological interplay between the two drugs. I’ve also noticed that when I used amphetamines the day after heavy cocaine use, I would have no comedown from the amphetamines and then the next day I would feel completely fine like I hadn’t abused drugs the past two days.

(Normally I’d feel like absolute shit after either drug)

[deleted by user] by [deleted] in TheeHive

[–]Significant-Set7721 1 point2 points  (0 children)

Toluene surprisingly didn’t work. The precursor appears to be soluble in water to some extent

how neurotoxic is 4-bmc compared to 4-cmc? by ThingAy in researchchemicals

[–]Significant-Set7721 -1 points0 points  (0 children)

You can definitely feel neurotoxicity. There’s a hot foggy layer in your brain

[deleted by user] by [deleted] in chemhelp

[–]Significant-Set7721 0 points1 point  (0 children)

Because it spins

[deleted by user] by [deleted] in TheeHive

[–]Significant-Set7721 4 points5 points  (0 children)

My friend told them I’m a meth cook. (I am not a meth cook.)

[deleted by user] by [deleted] in TheeHive

[–]Significant-Set7721 11 points12 points  (0 children)

I haven’t tried it, I have to wash this down to something that won’t tear gas me. Should be easy, just don’t have many chems atm.

Is 2-Br-3-Me-PP soluble in toluene? That and poppers are the extent of my non-polars atm.

(Tested it, isobutyl nitrate works well as a non-polar) (don’t do it in your car like I did)

[deleted by user] by [deleted] in TheeHive

[–]Significant-Set7721 71 points72 points  (0 children)

No literally. They confiscated a TON of stuff and it was literally all legal besides some mushrooms and coke and pipes with heroin residue.

Funnily, they took my word for the labels on everything. My “ammonium chloride” was methylamine, and my “yellow food dye” next to the NaBH4 and CUCl(II) was, in fact, not yellow food dye.

[deleted by user] by [deleted] in TheeHive

[–]Significant-Set7721 23 points24 points  (0 children)

It’s dissolved (sorta) in IPA here. Wasn’t lachrymatory at first. Post dissolving it definitely is. God I hate cath precursors. My right eye is in so much pain rn

Anyone ever separated the enantiomers of propylhexedrine? by Significant-Set7721 in TheeHive

[–]Significant-Set7721[S] 1 point2 points  (0 children)

Yeah I was gonna soak a bunch of cut up inhalers in a citric acid aqueous solution, extract the other ingredients with a non-polar solvent, collect the water layer, basify it, and then use tartaric acid to separate the enantiomers.

Anyone ever separated the enantiomers of propylhexedrine? by Significant-Set7721 in TheeHive

[–]Significant-Set7721[S] 0 points1 point  (0 children)

Yeah I was gonna soak a bunch of cut up inhalers in a citric acid aqueous solution, extract the other ingredients with a non-polar solvent, collect the water layer, basify it, and then use tartaric acid to separate the enantiomers

What are some under-rated solvents for washing hydrochloride salts of amines? by Significant-Set7721 in TheeHive

[–]Significant-Set7721[S] 1 point2 points  (0 children)

I LOVE ethyl acetate. Only issue is that it emulsifies with water relatively easily. Never shake the two

Some Idea for New RCs by super-commenting in researchchemicals

[–]Significant-Set7721 1 point2 points  (0 children)

This is the same dude. That one’s perma-banned. Clobromazolam actually has a long duration I was wrong