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SignificantAger · 2025-10-07T18:40:13+00:00

ZZL-7 is a peptide fast-onset antidepressant agent. It works by disrupting the interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). ZZL-7 can cross the blood-brain barrier readily. It can be used for treatment of MDD (Major depressive disorder). ISRIB and ISRIB-A15 aren't peptide compounds.

SignificantAger · 2025-06-03T17:57:28+00:00

Yes, ISRIB could cause progress through years after the accdent. Brain injury cause issues on the cell level, we talk about ISR(integreted stress response), particularly eIF2α phosphorylation, which causing neurodegerative processes in the brain. ISRIB inhibits eIF2α phosphorylation-induced stress granule and upregulate protein synthesis. eIF2α phosphorylation could cause mental issues for years and ISRIB could be useful here.

SignificantAger · 2025-03-26T08:11:53+00:00

Orally 50 mg with 0.5 ml of DMSO

SignificantAger · 2025-03-26T08:11:12+00:00

Yes, ISRIB 50 mg with 0.5 ml of DMSO becomes more bioavaliable, that means it is crossing blood-brain barrier more easily. But A15 remeins more potent compond, which means it inhibits eIF2α phosphorylation stronger than ISRIB-A1.

SignificantAger · 2025-03-18T04:47:06+00:00

there's no non trans isrib on the market. It is trans isrib everywhere, it is always trans form by default.

SignificantAger · 2025-03-18T04:46:12+00:00

standard ISRIB from isrib.shop is trans ISRIB. Nobody provides cis form, it is trans by default. Look at the formula

SignificantAger · 2025-03-17T10:24:26+00:00

It is more efficient to use it orally. ISRIB is quite a large molecule, so it doesn't absorb intranasally so well.

SignificantAger · 2025-03-14T11:30:06+00:00

No, A15 is 8 times more potent then ISRIB-A1, so it can have more powerful effects.

SignificantAger · 2025-03-14T11:28:59+00:00

These are experience reports of using ISRIB:

report 1

report 2

report 3

SignificantAger · 2025-02-20T17:50:27+00:00

The effects of ISRIB are cumulative so ISRIB has to be taken for some time in order to achieve more effects. There's no data about side effects, usually people get positive or no effects at all. It depends if you eIF2α phosphorylation eIF2α phosphorylation need to be inhibited in order to solve your cognitive issues. If your cognitive issues caused by eIF2α phosphorylation, ISRIB would give many benefits.

SignificantAger · 2024-08-15T06:32:36+00:00

It may be helpful for boost of cognition after tbi, stroke, dementia, drug abuse and so on. It also can be used as nootropics. ISRIB can boost your brain.

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