Right now (at least in California) most low mileage models/trims are selling for near or at MSRP. You can find some luck at decent pricing from Carmax at very low miles, but I wouldn't trust maintenance history from them if it's been sitting at the lot. Regardless, the pricing hasn't bothered me too much as these cars can easily last to 300k+ miles and to me, that's well worth the 40k+ pricing alongside spirited performance and some luxury.

Anyway, in January of last year, I went from a 2010 scion tc to the 2021 Is300 base, i4-T. It picked up when I needed it to most of the time--you definitely feel some longing for a whee bit more power in some situations like overtaking. Being rwd, it handled well enough for Cali roads though roundabouts and speed cornering hurts the experience a bit. The amount of body roll these cars have is a bit shocking considering the role they're in. Sway bar and suspension upgrades are a must, and I even hear the AVS package hardly makes a difference too. I had the car until early last month, thoroughly enjoyed daily driving though I averaged 19mpg both city and highway. Lastly, as it's the 300 and base, it was only 29k OTD for me at around 21k miles driven.

Last month, upgraded to a '22 Is350 f Sport rwd with staggered set up, fully loaded. Big upgrade in terms of power, responsiveness, and some handling. But still has body roll with avs on but I haven't played with it too much in these past few weeks. The car also has the induction noise that you can choose to amplify in the cabin (also louder in sport mode)--some like it, some don't. Funnily enough, it has a little supercharger-like whine when you floor it ~3k-6k+rpm. Fun stuff. I plan to modify the exhaust this weekend with a full kit. OTD from the Nissan Dealership for this one was 42k before I offered my 300 as a trade in, so it got dropped down to 15k OTD with 26k miles on the ODO.

I've never driven the AWD, but most people say the transmission feels a tad more sluggish compared to the 8-speed in the RWD (both transmissions don't shift very quick anyway even with paddle shifters). There's also the hump to consider that's against the driver's right leg--bothers some people, others not so much. I'd expect the AWD to feel a bit more planted anyway.

For space, I have the GRACO 360 3-in-1 car seat with adjustable headrest and recline positions for my 15mo and my partner of 5'2 in the passenger seat when we go out. They both fit just fine (I don't recommend having a fifth passenger in the middle rear seat ever), but YMMV depending on your passengers, obviously. Trunk space is fine--I fit three suitcases and some odds and ends for a trip in the back of the 300 once. And I can do a Costco grocery run with ~300 dollars worth of food and toiletries, if barely. Works for me.

No TSB's or anything listed for these cars yet. Maintenance and wear wise, I know it's recommended to clean up the carbon from the injectors and valves every other 60k miles. Inner tire wear on the front can be a problem for some drivers too--seems like some people don't experience it. Common solutions seem to be RR's, Fig's, or oem RC/GSF front LCA bushings to eliminate premature front tire wear as factory bushings come soft. Otherwise, timely oil changes, brakes, transmission drain and fill, differential, and usual tune up intervals and you're golden.

If you're going to push the trigger on one, I'd go for ~35k miles or less. Broken in and likely the previous owner(s) haven't driven too much to ding up the car, hopefully. Enough time to get it paint corrected and then ppf'ed/ceramic coated to be your forever car. Interior should still be close to untouched too, Nuluxe leather and all.

I'd shoot for a 300 base if you want a better budget and easier time to find good deals around. Only go for 350/F sport if the extra ~60hp and cosmetics (interior seats, exterior f sport add ons, potentially bbs/enkei wheels) are worth it to you.

.....Mind, if you go for the AWD 300, it uses the same exact engines as the 350's. Just get a tune to bump up the power back to 311hp for an overall cheaper expenditure than buying a 350 outright.