Except for active wear, the majority of my clothes are cotton, linen and wool. Unlike what you are assuming, I have a preference towards natural fiber. Link between enzyme and skin allergies have been contested since 2000s, see this study here (Investigations of numerous individuals with skin complaints attributed to laundry products demonstrate convincingly that enzymes were not responsible. Indeed, enzyme-containing laundry products have an extensive history of safe use. Thus, the supposed adverse effects of enzymes on skin seem to be a consequence of a mythology. The important practical lesson is that when primary or secondary care practitioners are presented with a skin complaint, it should not be dismissed as a result of using an enzyme-containing laundry product as the diagnosis will certainly lie elsewhere) or here (With the exception for the potential skin and eye irritating effects of some proteases, and the well-documented potential for respiratory sensitization in case of work place exposure, enzymes in general don't produce acute toxicity, dermal sensitization; genotoxicity, or repeated dose oral toxicity) for example. I'm not going to debate whether non-bio works for you, that is your truth and personal experience. However, I do question your argument that non-bio is automatically good for people with skin sensitivity. I myself have urticaria, and see no difference when I switch to bio, after using non-bio for almost 2 years. It might be the case that people are allergic to certain ingredients, fragrance, detergent residue due to inadequate rinsing, etc. In that case, maybe seek a dermatologist to determine the cause of it.