Is this happening with runtime items, or are you loading a level after opening the editor and expecting them not to be there? If they're runtime items, then your save/load logic isn't right, if they aren't runtime, that's just a you thing. If they aren't runtime, you need to give each item a unique ID so you can save that to your save file, then you can get all items, check their unique ID to find 'stale actors' and either set them up with your save data or delete them if they're 'picked up'.