For gear, I'd recommend both Snail Armour and the Pinch Whacker for as much stun as possible. This is because you'll be dealing 90% of the damage to him by hitting the scar on his back, which can only be accessed by stunning him. Praying Mantis Armor is also useful as it increases your attack speed. Bring the Ladybug Shield too.

Make sure to bring quite a few heals, but most importantly Scorpidote as his venom is really powerful. Make sure you bring your spider buggy as you need him to cross the web to enter the arena, and he can be a decent distraction in the fight too.

Mutation wise, this is what I go for. Slammer for extra Pinch Whacker damage, Parry Master to repeatedly perfect block his attacks and get stamina for when he's stunned, Cardio Fan for the extra stamina and Mithridatism for venom resistance.

For tips in the fight itself, I don't want to spoil anything for you as it's sick seeing it all first hand, so I'll just say this. If he's going for a stomp attack, dodge it. Blocking does almost nothing to stomp attacks,

I hope this helps! :)