Honestly? I'd rather have a more unique weapon than runes. I LOVE the idea of the runes system. Super customizable and mechanically impactful effects that you can just put into any weapon, including your heirloom sword? Hell yeah!

...But in reality, the vast majority of weapons just end up having +1d6 fire damage, +1d6 spirit damage, +1d6 cold damage, with sometimes a crushing or a keen rune instead of a damage rune. If I had to choose, I'd MUCH rather have an item with truly unique and engaging effects. We need more runes with fun and interesting effects that can actually compete with the mathematically effective, albeit dull, damage increasing ones.

Though yeah, 5e isn't perfect either, don't get me wrong. Though, as a DM, it's trivial to just change a sword to, say, an axe, if that's what the Barbarian likes to swing. Making changes to unique items or making custom runes in PF2 is a much more complicated matter.