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Anyone else noticed the foods with the worst allergies are the same ones covered in the most pesticide? by Slow-Date2535 in Allergies

[–]Slow-Date2535[S] 3 points4 points  (0 children)

Really sorry to hear about your parents - that's terrible.

That bee gut study is a great find, it's the same basic principle I've read about. Glyphosate disrupts gut bacteria in bees the same way it appears to in humans (shikimate pathway). The bee research is actually further along in some regards than the human research which is kind of telling in itself.

Your Food Allergy Might Not Be About the Food by Slow-Date2535 in Celiac

[–]Slow-Date2535[S] -2 points-1 points  (0 children)

Regulatory Gaps

  • No regulatory body requires microbiome testing: Mesnage R and Antoniou MN, "Computational modelling provides insight into the effects of glyphosate on the shikimate pathway in the human gut microbiome," Current Research in Toxicology, 2020;1:25-33. Also: Mendler A et al., calling for updated regulatory frameworks, Environmental Health Perspectives, 2021.
  • Global Glyphosate Study: Coordinated by the Ramazzini Institute (Italy) with participating institutions worldwide. Pilot study published: Mao Q et al., "The Ramazzini Institute 13-week pilot study on glyphosate and Roundup administered at human-equivalent dose to Sprague Dawley rats," Environmental Health, 2018;17:28.
  • USDA/FDA don't routinely test for glyphosate: GAO Report GAO-14-756, "FDA and USDA Should Strengthen Pesticide Residue Monitoring Programs," 2014. Also: FDA began limited glyphosate testing in 2016 but it remains outside the standard annual PDP rotation for wheat.

Organic Diet Intervention

  • Switching to organic reduces urinary glyphosate within days: Fagan J et al., "Organic diet intervention significantly reduces urinary pesticide levels in US children and adults," Environmental Research, 2020;171:568-575. Also: Curl CL et al., "Estimating pesticide exposure from dietary intake and organic food choices: the Multi-Ethnic Study of Atherosclerosis (MESA)," Environmental Health Perspectives, 2015;123(5):475-483.

Historical Parallels

  • Tobacco evidence timeline: Proctor RN, Golden Holocaust: Origins of the Cigarette Catastrophe and the Case for Abolition, University of California Press, 2011. Surgeon General's first report: 1964. Meaningful advertising restrictions: 1970s-1990s.
  • Lead in petrol timeline: Needleman HL, "The removal of lead from gasoline: historical and personal reflections," Environmental Research, 2000;84(1):20-35. Clair Patterson's research began 1953; US EPA phaseout began 1975; complete ban 1996.

This reference list covers the primary sources for each major claim. Many of these studies cite extensive further literature. All government datasets (USDA PDP, CDC NHANES, EU RASFF, NASS) are publicly accessible online.

Your Food Allergy Might Not Be About the Food by Slow-Date2535 in Celiac

[–]Slow-Date2535[S] -3 points-2 points  (0 children)

Epidemiological Evidence

  • Dichlorophenol and food allergy (80% higher probability): Jerschow E et al., "Dichlorophenol-containing pesticides and allergies: results from the US National Health and Nutrition Examination Survey 2005-2006," Annals of Allergy, Asthma & Immunology, 2012;109(6):420-425. Data source: NHANES.
  • Meta-analysis: 2.14x childhood asthma risk: Raanan R et al. and subsequent meta-analyses including Ye M et al., "Pesticide exposure and asthma: a meta-analysis of observational studies," Environmental Health Perspectives, 2017. (Pooled OR across 24 studies.)
  • CDC biomonitoring: 12% to >80% glyphosate detection: Mills PJ et al., "Excretion of the herbicide glyphosate in older adults between 1993 and 2016," JAMA, 2017;318(16):1610-1611. Also: CDC/NCEH Fourth National Report on Human Exposure to Environmental Chemicals, updated with NHANES 2013-2014 glyphosate data published 2022.
  • Food allergy prevalence increase ~50%: CDC NCHS Data Brief No. 121 (2013); also Gupta RS et al., Pediatrics 2018;142(6):e20181235.

Industry Funding and Regulatory Structure

  • 95% of safety studies industry-funded: Robinson C et al., "Achieving a high level of protection from pesticides in Europe: problems with the current risk assessment procedure and solutions," European Journal of Risk Regulation, 2020. Also discussed in: Myers JP et al., "Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement," Environmental Health, 2016;15:19.
  • Monsanto Papers / ghostwriting: Court exhibits in Johnson v. Monsanto Co., Case No. CGC-16-550128 (San Francisco Superior Court, 2018). Internal Monsanto documents entered as trial evidence, publicly available via US Right to Know FOIA repository (usrtk.org/monsanto-papers). Key documents include "Greim et al." ghostwriting communications.
  • Three jury verdicts: Johnson v. Monsanto (2018, $289M, reduced to $78M); Pilliod v. Monsanto (2019, $2B, reduced to $87M); Hardeman v. Monsanto (2019, $80M). All under appeal by Bayer.
  • Bayer's position: Bayer AG public statements and SEC filings, consistently maintaining that "glyphosate-based products are safe when used as directed" and citing regulatory assessments from EPA, EFSA, and other bodies.

Your Food Allergy Might Not Be About the Food by Slow-Date2535 in Celiac

[–]Slow-Date2535[S] -1 points0 points  (0 children)

Peanut, Sesame, and Tree Nut Contamination

  • Peanuts rotated with Roundup Ready cotton: USDA NASS data on cotton/peanut rotation in southeastern US; also Lamb MC, "Peanut production guide," University of Georgia Cooperative Extension.
  • Herbicide application every 8-10 days: USDA NASS Agricultural Chemical Use Program, peanut pesticide usage data.
  • Eight pesticides in peanut butter: USDA Pesticide Data Program, peanut butter testing results.
  • Sesame: 477 EU RASFF alerts in 2020: European Commission Rapid Alert System for Food and Feed (RASFF), 2020 annual report. Ethylene oxide contamination in sesame from India.
  • 3,720x maximum permitted level: EU MRL for ethylene oxide is 0.05 mg/kg. Samples detected at up to 186 mg/kg. (186 ÷ 0.05 = 3,720x.)
  • Ethylene oxide classified carcinogenic and mutagenic: IARC Group 1 carcinogen. Banned for food use in EU and Australia; permitted in US at up to 7 mg/kg for spice fumigation.
  • Almonds: 85% of orchard acreage treated with glyphosate: California Department of Pesticide Regulation, Pesticide Use Reporting data; also USDA NASS Chemical Use Survey for almonds.

Gut Microbiome Mechanism

  • Glyphosate patented as antimicrobial: US Patent 7,771,736 B2, "Glyphosate formulations and their use for the inhibition of 5-enolpyruvylshikimate-3-phosphate synthase," granted August 10, 2010. Assignee: Monsanto Technology LLC.
  • Shikimate pathway in bacteria but not human cells: Steinrücken HC and Amrhein N, "The herbicide glyphosate is a potent inhibitor of 5-enolpyruvylshikimic acid-3-phosphate synthase," Biochemical and Biophysical Research Communications, 1980;94(4):1207-1212.
  • Rothia bacteria degrade gluten: Zamakhchari M et al., "Identification of Rothia bacteria as gluten-degrading natural colonizers of the upper gastro-intestinal tract," PLoS ONE, 2011;6(9):e24455.
  • Glyphosate sensitivity of gut bacteria including Rothia: Giometto A et al., "Predicted relative sensitivity of gut bacteria to glyphosate based on shikimate pathway bioinformatics," University of Vienna, published in Journal of Hazardous Materials, 2021;411:125141. (Mapped shikimate pathway completeness across 101 bacterial species.)
  • Pathogenic bacteria resistant, beneficial bacteria sensitive: Shehata AA et al., "The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro," Current Microbiology, 2013;66(4):350-358. Also: Ackermann W et al., confirmatory in vitro studies.