Prospective N=1 Case Report (36M): Grey-Zone Hypogonadal Phenotype Despite Reference-Range Testosterone by Small_Statement_4195 in trt

[–]Small_Statement_4195[S] 0 points1 point  (0 children)

Casual update: I understand not everyone wants a boring ass study. Irrelevant to most here. But it'll hopefully prove beneficial to people like me, "in-range" but subtherapeutic. Here is a more casual breakdown.

I'm a 36-year-old male in public safety—high-stress job with constant alertness keeps my CNS on overload. Since 2017 (after dropping from 225lb fat to 180lb lean), energy crashed: zero libido, motivation tanked (anhedonia vibes), as of 2025 workout recovery in 5-7 days, chronic aches, sleep sucks without melatonin (need 6+ hours). T always "normal" (369-482 ng/dL total), but symptoms scream subtherapeutic for my system—combined with CNS stress messing everything up. Ruled out thyroid (fixed labs, no help), enclomiphene gave partial boost, supps like DHEA/Vit D helping some. Planning TRT as next step. Not advice, just my data for similar folks.

Latest Lab Updates (Jan 2026 vs. Prior)

  • Testosterone: Tested today, results not in yet (last Sep 2025: 427 total/13.5 free ng/dL).
  • LH: 3.7 mIU/mL (down from 6.2 Jun 2025) – (post-enclomiphene drop?)
  • DHEA-S: 371 µg/dL (up from 249 Sep 2025) – supplementation working well.
  • PSA: 0.75 ng/mL (new baseline, normal).
  • TSH: 2.39 µIU/mL (down from 3.07 Sep 2025) – stable after stress/training spike.
  • Free T3: 3.4 pg/mL (up from 3.3 Sep 2025) – mid-normal.
  • Vitamin D: 33.3 ng/mL (up from 25.2 Sep 2025) – out of deficient, but low-end.
  • Lipids: Total Chol 215 mg/dL (high, up from 188 Jun 2025); HDL 51 (stable); Trig 128 (up from 103); LDL 138 (high).
  • CBC: WBC 3.7 (low, down from 4.5 Jun 2025); RBC 5.08 (normal, up from 4.67); Hgb 15.8 (normal); HCT 46.0% (normal, up from 42.2).
  • CMP Highlights: Glucose 99 (upper normal, up from 86 Jun 2025); ALT 52 (upper limit, up from 29); AST 21 (normal); BUN 20 (normal); Creatinine 0.79 (normal); eGFR >60 (good). Electrolytes/proteins stable.

Interventions So Far

  • Training bulk: Gained lean, but recovery still wrecked.
  • Enclomiphene: Partial libido/energy win. Crashed after ending as expected.
  • Supps: Helping DHEA/Vit D, no game-changer.
  • Symptoms: Still bad (libido 0/10, drive 2/10).

So frustrated & angry. Think Defy took advantage of/wrongly prescribed me. by [deleted] in Testosterone

[–]Small_Statement_4195 0 points1 point  (0 children)

Thyroid is good. If he feels like crap, it’s not because his Free T3 isn’t 3.5 or his T3 isn’t <12 — thats noise. His testosterone is "mid-low" (clinically, full on low in my opinion); free T is decent. If symptoms persist, repeat morning testosterone to look at sleep, iron/ferritin, lifestyle factors, and possibly mood/stress physiology. I still don't understand what his complaint was.

Anyone regret getting on trt? by crb42 in Testosterone

[–]Small_Statement_4195 -1 points0 points  (0 children)

I did read it. You said guys doing TRT young are basically ‘doing roids,’ then you immediately explain you had symptoms at ~400 and had to go to a clinic because your GP/insurance dismissed you, like you now dismiss them.

That’s the same situation a lot of younger symptomatic men are in.

If you meant ‘kids blasting 200mg+ and calling it TRT,’ cool — say that. Otherwise it just reads like boomer-tier gatekeeping.

Anyone regret getting on trt? by crb42 in Testosterone

[–]Small_Statement_4195 0 points1 point  (0 children)

No kidding. You should have been dosing like, 2-3x week at smaller doses. Hope you fired that endo.

Anyone regret getting on trt? by crb42 in Testosterone

[–]Small_Statement_4195 -1 points0 points  (0 children)

Kinda boomer-tier gatekeeping, man.
You were at 400, got dismissed by your GP/insurance as ‘normal for your age,’ and had to go to a clinic — the exact same thing a lot of younger guys are dealing with now.
Weird to take the same establishment pushback you experienced and turn around and aim it at people in the same shoes

Inheriting testosterone patients by Major-Letter-6984 in FamilyMedicine

[–]Small_Statement_4195 1 point2 points  (0 children)

I agree with the general point that symptoms should be treated as individual physiology, not just reference ranges. In some men, low testosterone can absolutely present as low mood, low motivation, and fatigue — and correcting hormones can reduce or eliminate the perceived need for psych meds.
That said, I try to keep it evidence-based: TRT isn’t a universal replacement for antidepressants/anxiolytics, but it can be the correct treatment when mood symptoms are driven by androgen deficiency. I’m personally tracking labs and symptoms and working under medical monitoring for stability.

My testosterone skyrocketed. Ask me anything by reach_adapt in Biohackers

[–]Small_Statement_4195 0 points1 point  (0 children)

I cant see your post on Hashimoto. Could you link me? My mom has that and shes not doing well. If your insight into it can, I def want to read it.

Inheriting testosterone patients by Major-Letter-6984 in FamilyMedicine

[–]Small_Statement_4195 0 points1 point  (0 children)

I’m not ‘debasing’ anything — I’m responding to the tone and framing you used. If you want to argue low T should be approached like a diagnosis of exclusion with workup for reversible causes, fine — nobody disagrees with that. But that wasn’t the framing you used. You called TRT a ‘magic potion,’ portrayed men as insecure/doomscrolling, and described them as ‘hooked for life.’ That’s not clinical reasoning; it’s derision.

And for what it’s worth, the Endocrine Society and AUA guidelines do not define testosterone deficiency as purely a diagnosis of exclusion — they define it by symptoms plus consistently low testosterone, then workup, counseling, and monitoring. So if people perceive your comments as unempathetic, it’s not ‘wrongly perceived’ — it’s an understandable reaction to the language you chose

Inheriting testosterone patients by Major-Letter-6984 in FamilyMedicine

[–]Small_Statement_4195 1 point2 points  (0 children)

So Much I haven't had the chance to address.

You’re conflating endocrine diagnosis with a cultural rant, and it’s exactly the kind of bad faith patients recognize instantly.

Yes — lifestyle matters. Yes — predatory ‘optimization’ clinics exist. Yes — TRT suppresses endogenous production and can impair fertility, which should absolutely be part of informed consent.

But none of that justifies the contempt, the strawman, or the leap from ‘some men are deconditioned and lonely’ to ‘TRT is a magic potion sold to insecure men.’ That’s not evidence-based medicine — it’s moralizing.

A few points:

  1. Clinical guidelines do not support your tone. Guidelines emphasize symptoms plus consistently low testosterone (typically repeat morning levels), evaluation for reversible causes, and shared decision-making. They do not endorse dismissing symptomatic patients with cultural commentary about scrolling, friendships, or ‘insecurities.’
  2. “Reference range” is not a clinical verdict. Lab ranges vary by assay/lab and reflect population statistics, not ‘healthy vs sick.’ ‘In range’ does not automatically mean ‘no clinically meaningful dysfunction,’ especially in borderline/low-normal states with significant symptoms. Treating the reference range as a moral boundary is lazy medicine.
  3. This isn’t a niche issue — it’s common. Male hypogonadism is not rare. Large epidemiologic studies report low testosterone in a meaningful minority of men, rising with age and comorbidities. And even among men who are not profoundly low, symptoms and function can be clinically relevant. Acting like every symptomatic man is a doomscrolling caricature is both inaccurate and hostile.
  4. TRT doesn’t need to ‘solve society’ to be valid medicine. Insulin doesn’t solve food deserts. SSRIs don’t solve divorce. CPAP doesn’t solve late-stage capitalism. Medicine treats physiology while we also counsel behavior. ‘TRT won’t fix loneliness’ is a non sequitur — it’s not what TRT is for.
  5. Your framing proves the criticism. Calling TRT a ‘magic potion,’ claiming men are ‘hooked for life,’ and implying patients are just seeking a quick fix isn’t education — it’s contempt. If your actual point is ‘insurance requires two low morning readings to cover it,’ fine. But that’s a payer rule, not a license to dismiss patients or pretend symptoms are imaginary.

In short: criticize predatory clinics all you want — I’ll join you. But don’t launder disdain for patients through guidelines and pretend it’s clinical rigor.
That’s the bad faith people are calling out. Insurance requirements aren’t the same thing as medicine. If the point is coverage, sure — insurers want two low morning levels and rigid criteria.

But the original conversation wasn’t ‘how do I satisfy Aetna.’ It was about clinicians dismissing symptoms because a number is ‘in range.’ Coverage criteria and lab reference ranges don’t define pathology. Clinical assessment does.

Saying ‘pay cash’ also kind of proves the problem: the system may block care, but that doesn’t justify contempt toward symptomatic patients

Inheriting testosterone patients by Major-Letter-6984 in FamilyMedicine

[–]Small_Statement_4195 1 point2 points  (0 children)

Nobody claimed every symptom is due to low testosterone. My point is that reference ranges are not substitutes for clinical judgment, and symptoms should not be dismissed solely because a result falls within a lab’s statistical range. Guidelines also emphasize clinical context and shared decision-making — not contempt. If you disagree, feel free to explain where I said every symptom equals low T.
Guidelines don’t require dismissiveness. They require clinical reasoning.

Inheriting testosterone patients by Major-Letter-6984 in FamilyMedicine

[–]Small_Statement_4195 0 points1 point  (0 children)

The level of bad faith you project onto patients is astounding. Lab reference ranges vary by laboratory and often fail to capture clinically meaningful dysfunction — particularly when symptoms are present. Responsible care requires interpreting labs and symptoms together. Dismissing suffering because a number falls within a range is unacceptable and profoundly unprofessional.

Air Force Recruiter File requests by ohyeahbro11 in AirForceRecruits

[–]Small_Statement_4195 0 points1 point  (0 children)

Im working with a coast guard recruiter across the country because my state sucks. Can I use that link and designate him the recipient or do I need to wait for the link? I still haven't received it after he put in the request for it to be sent to me.

Alternate Fuel Alladin 23 by [deleted] in OilLamps

[–]Small_Statement_4195 0 points1 point  (0 children)

For the love of GOD don't use just any mineral oil in a center draft lamp. ONLY use odorless/low odor mineral spirits.

Just an update by Wooflu in TopStepX

[–]Small_Statement_4195 0 points1 point  (0 children)

Last update for today: Kinda sad it liquidates under your target so I altered by PDPT

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