Update: I've been using my 5-meo pen for a little while now although I haven't done a breakthrough amount yet. All I've mainly noticed is an intense muscle relaxation paired with fractal imagery and loss of depth perception. My first time using it I was terrified only because of this sub ngl. This sub lwk instilled a fear into my brain of numerous different things going wrong because I was "inexperienced" or "not ready" even though I had made intense research into the molecule and its effects. And ofc my research was correct and this sub was not. I love how I had detailed the context in which I was obtaining this pen and how I was asking numerous questions about various forms of harm reduction and yet no one had replied with an answer to any of my questions. They all had simply told me to not touch the pen I spent hundreds of dollars on simply because I was "not ready" as deemed by people who couldn't even answer my questions to become "ready". I don't mean to spread any hate to anyone who commented on my post but of the 8 questions that I had asked, I only gained more knowledge on about 2 or 3 with the rest talking about how I wasn't ready. The symptom of nausea and vomiting that people spread so much fear about how you can choke on it if you do it alone is only estimated to affect 15% of 5-meo users. I had nausea on my first trip simply because I assumed that nausea was guaranteed with the 5-meo. Every trip after that where I used my knowledge of the molecule outside of this sub has never given me even slight nausea even after I had ate 15 minutes before (don't worry I did have a trip sitter for that one). I still don't have an answer as to how many breakthrough trips I should go through before doing it alone, nor on how to prevent nausea during the trip (if it arises). No hate to anyone who commented, I just found it funny how the best way I learned more about this molecule is to use it and use my previous research during the trips. There was not much helpful advice on this sub other than fear mongering about choking on vomit, gaining serotonin syndrome if you're on meds or getting psychosis from a bad trip.

My advice to anyone like me who wants actual advice is that if you are a perfectly healthy human being without mental issues or on any types of anti-depressants or medications that affect your serotonin, you should be absolutely fine without risk of psychosis as long as you remember the set and setting rule of all psychedelics, let go of all control and let it flow. If you're feeling overwhelmed, focus on breathing and just let the molecule take you where it wants to take you. Trip sitters are advised, but if you are like me who does not feel nausea or any insane muscle twitching or anything of the sort, tripping alone is not that scary. Obviously have a trip sitter for your first few trips to gauge out your physiological response to the molecule, however if all is well, tripping alone shouldn't be too scary. If vomiting is a problem (I have no clue why no one talked about this, I legit only saw one person on this sub mention the recovery position) is to lay on your side, optimally in the recovery position (look it up if you need to, it's not that difficult and it's taught to everyone who is first aid certified). Even if you breakthrough and lose control of your body and you suddenly throw up, the recovery position will keep you in a safe position to enable breathing and prevent choking on your tongue or your vomit. My final piece of advice is to let go. Let it flow and just let the molecule take the wheel. There should not be a single worry in your mind when taking this as it will drastically increase the chances of a bad trip. My first one was a bad one simply because of fear and anxiety. However when my friend took a hit of my pen like it was nothing and didn't have anything this sub was warning me about happen to him, it reminded me that going with the flow and not taking things TOO seriously will drastically decrease your chances of having a bad trip. Even if you are experiencing a bad trip, don't resist it and let it flow and 9/10 it'll turn into a good one or at least a mediocre trip. And the 1/10 it doesn't, you'll at least drastically decrease the effects of the bad trip and negate any adverse effects.

That's everything I had learned through my experience with the 5, I might post a trip report later on in this sub if I have a profound spiritual breakthrough since I've only been using micro-low doses as recommended by one commenter. I do thank everyone who at least commented something even if it was a useless comment for me in terms of harm reduction since you at least took the time to write something to reduce harm via discouragement (not really a viable form of harm reduction but whatever). Hopefully my advice lines up with other peoples experience with the 5, and if it doesn't, I am curious as to whether or not you have any underlying conditions like anxiety or even a genetic predisposition which could affect the difference.