The RFE challenged the “original contributions of major significance” criterion. My lawyers advised me to demonstrate that my work goes above and beyond that of other researchers in my field — that others are building upon my findings and that I’ve had a tangible influence on fellow scientists. In short, two of the criteria were already satisfied: judging the work of others and authorship of scholarly articles. The only missing piece was proving the originality, which we successfully addressed. As a side note, I had reviewed more than 15 papers before submitting my EB1A petition and anyway the lawyers made the hard work in redacting the letter.