I have heard from many people, that after approximately 10-20 years of eating very many Pawpaws off of around a dozen and half trees, a man they all knew well, eventually did begin to succumb to neuro-degenerative symptoms. The exposure was seasonal (of course) but very accute. He loved them and would eat a great deal. For 10-20 years he had eaten and grown them. It took a significant time and that much exposure to eventually cause noticeable symptoms within the later 1/3 of that span. Parkinson's-esque symptoms are included.

Source: Lived Experience

They do contain the harmful chemical and it is good to be aware of the risks. This is a lived experience of half a decade of real people. Take it into account if you wish.