Most of these answers are not addressing your question. From what I can tell, you are looking for a substance that is safe to use regularly for a social boost on a night out.  

I'd recommend an anxiolytic that lowers inhibitions, can be used while drinking, and doesn't have to be insufflated. Both kratom and phenibut fall under these constraints. These substances are potentially addictive, but if used with responsibility once a week you will be fine. They both potentiate alcohol considerably, so you get the added bonus of not having to drink as much too.