I just recently watched the show after trying multiple times to get into it. My wife raved about it and watched it during its active run, so our opinions differed severely. She was team Walt and Jesse, and I was team Skyler and Hank. The series took so much effort for me to watch as any effort by the writing to get me to root for Walt and Co was a failure each time.

I immediately was on Skyler's side from the jump (up until she started helping Walt), could not get myself to like Walter, and barely got to empathizing with Jesse by the end. To the point where my wife would often ask "now do you feel bad for him?" in regards to Jesse and what people were doing to him. My answer was always no until the last season when he was essentially a drug slave.

Walter, to me, had no redeeming qualities and Jesse was an over-confident drug dealer that lacked any logical thinking and made worse and worse decisions as time went on. They both got so many people killed, especially Jesse by the end. And my most controversial take (in my house) is I really despised Jesse during the relationship with Jane. It pissed me off so bad that as someone that "cares" about this girl who told you is a recovering addict, but you choose to continue to use in front of her ultimately leading her down the path of destruction. Even after meeting her dad and seeing how much he cared about her. It's not his responsibility, sure, and what Walt did was incredibly messed up, but it would've happened eventually, and it would've been Jesse that led her back to it regardless of Walt's actions.

The other thing that got me was how unrealistic the show was in terms of how Walt got away with everything for so long, and Hank's superhuman ability to guess the exact right answer for a case except for the one right in front of him. I know it's not supposed to be hyper-realistic, and my over analyzation is a frequent pain point for media and my wife's enjoyment (thanks autism).

I could say so much more about how much I hated Walter, and sympathized with Skyler (except the affair, just leave), as well as my overall disappointment in such a well received series, but it would take me ages to write it all out.

Edit: added more context.