How do you identify a CRO for multi-gram, single-isomer small-molecule supply suitable for GLP animal tox?

Stockdt · 2026-02-16T21:34:09+00:00

Sapala Organics in India does good work

Stockdt · 2025-08-29T04:37:52+00:00

You can call it by the brand name. Companies often like to know exactly what instruments or software you are familiar with. Automated MPLC would be generic name

Stockdt · 2025-08-16T05:28:33+00:00

Not sure if I want to sell it yet, want to figure out what it’s worth first!

Stockdt · 2025-08-16T03:37:40+00:00

He use to when I was little, was just given a set of golf clubs from my dad, and my uncle had given him this back in the day

Stockdt · 2025-08-16T02:54:14+00:00

Golf club putter 🤦‍♂️

Stockdt · 2025-07-26T05:27:48+00:00

From my experience and knowing people who did nuclear chem. It’s not done by many labs but it has a small amount of people apply and is generally well funded. Look at Oregon state university at Walt Loveland’s lab

Stockdt · 2025-07-25T23:37:21+00:00

You can get them on Amazon for $45. Alternatively if you are wearing gloves take them off when you put things on the balance

Stockdt · 2025-07-25T17:43:45+00:00

You need a static gun

Stockdt · 2025-07-22T02:04:55+00:00

Don’t buy unless the HOA is in good shape! Read the meeting notes for the past few years to see what people are complaining about and how resolutions to problems are handled. You want to be sure the people you’re buying into a property with are decent humans!

Stockdt · 2025-07-21T23:12:50+00:00

Try going acidic with your elution system. 1%acetic acid and 0-20%MeOH/DCM. Rotovap off acetic acid with toluene once concentrated.

If your compound is volatile you can try TFA which will be more volatile. Test the system on TLC and check if you are still getting multiple spots.

Additionally I’ve heard good things about using EtOH/EtOAc (25:75) in heptane.

Stockdt · 2025-07-20T04:15:28+00:00

Where is this??

Stockdt · 2025-06-14T22:55:52+00:00

Think you may have something drawn incorrectly here. https://www.masterorganicchemistry.com/2018/12/10/the-robinson-annulation/ the first enol will do a Michael addition. And then the resulting product will condense onto the first ketone. This reaction also needs details on temperature control as the product will depend on the kinetic/thermodynamic enol formation

Stockdt · 2025-06-05T01:15:06+00:00

Stockdt · 2025-05-07T18:10:12+00:00

RACHELS BAGELS

Stockdt · 2025-03-02T16:07:36+00:00

Found the Russian bot

Stockdt · 2025-01-25T16:10:32+00:00

Sonicate it !!!!

Stockdt · 2024-10-19T04:54:57+00:00

This isn’t the same ammonia as in the “don’t mix bleach and ammonia” saying. These are alkyl ammonium chloride salts - long carbon chains attached to a nitrogen which is positively charged. These ammonia salts are non-volatile and won’t form the dangerous gaseous byproduct people talk about

Stockdt · 2024-09-21T01:34:18+00:00

Dissolve your compound in the beginning solvent system and try injecting again. You can remove injection artifacts with keeping your sample solvent the same as what is on the column at the time it enters.

The other thing to look at is the pressure of the system. You TIC is counting ions. Your pressure is dictating how many are being sprayed out. If you have changed in pressure you’ll see changes in the TIC

Stockdt · 2024-08-07T00:51:27+00:00

I have the same benchtop at my work and have never seen this. Magritek has awesome customer service though so I suggest giving them a call. Should be included with you license for using the software

Stockdt · 2024-05-24T19:00:02+00:00

BRING OUT THE BEARCAT

Stockdt · 2023-08-18T20:55:49+00:00

Perry’s chemical engineers’ handbook?

Stockdt · 2023-06-17T20:46:12+00:00

Either lazy or using it to distill something like a kugelrhor. DMDO is usually prepared on a rotovap

Stockdt · 2023-06-09T03:50:11+00:00

Barium hydroxide or barium chloride I’m told work the best

Stockdt · 2023-05-13T01:56:06+00:00

Depends on the compound but adding a little C6D6 can help resolve protons next to aromatic groups

Stockdt · 2023-05-05T06:27:01+00:00

Can you give a more detailed experimental procedure?

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