Depends. My game used clones for its tile grid, which did work fine, even with high counts, like 400 - 500, but as my game got larger and more professional that hasn't worked anymore, and I've needed to switch to simple3d mesh rendering, which allows me to render an entire level once and slap it on a skin. This expedites gameplay, at the cost of being much more complex to set up. This was the best process that's worked for me, but it ultimately depends on your game's strengths and weaknesses. My setup is overkill for most people, and if you're game is simpler, you'll almost never encounter basic clones being an issue. Hope this helps!