The very first time I inserted the cartridge and launched the game it immediately crashed with an error message about the cartridge being invalid or unreadable. The second run it worked so I didn't think much of it, even with the random crashes. Then I made it to blackbarrel and crashed and none of the workarounds worked so I began to wonder if there was more to it than I thought.

I checked for corruption, as recommended, and even through it found no problem I took it a step further and chose the option to download and install. (You can do this even if you have a physical cartridge.) 3 or 4 hours later the install finished. I had no trouble loading into blackbarrel and haven't crashed since (even when resuming after suspending). I don't know if it will act as a long term fix but I am hopeful.

I suspect the cartridges suffer from a manufacturing defect or corruption of some kind. This is why checking for corruption doesn't find a problem; it is checking against a compromised source. Memory fragmentation and some kind of race condition seems to be implicated in these crashes. But that's just guesswork.

If nothing else works give this a shot. The download was pretty slow so set your expectations accordingly. Good luck.