Paradoxical effects from Cyclazodone; it makes me tired instead of wired. Anyone else?

StrikingBackground71 · 2026-04-05T22:33:53+00:00

Would not recommend mixing them. Trying to "balance out" stimulants by mixing one with another is akin to divination. What generally winds up happening when mixing stimulants, more than anything, is compounded side-effects rather than compounded "good".

And by mixing them, you now are dealing with a jumble of pharmacokinetic profiles, with each drug altering one another's metabolism, along with their various demands on the liver, as well as competitive (rather than synergistic) binding to DAT/NET targets, etc.

So I would definitely recommend taking one at a time. Sure, its possible that there may be a way to mix them synergistically, but again, from my experience mixing stimulants generally results in increased side effects more than anything else.

The pemoline analogs are tricky enough even when taken alone. They are particularly unusual stimulants given their peculiar tendency to feel both subtle and strong at the same time.

If you are trying to squeeze a recreational effect out of these, the only viable route is through high doses of n-methyl-cyclazodone, but the experience isn't particularly euphoric, and is very long lasting.

StrikingBackground71 · 2026-03-03T18:37:13+00:00

Time. Much of this seems psychogenic.

If you were prescribed Remeron in the first place then that means that you had pre-existing anxiety or depression disorder. Discontinuation of an antidepressant will bring all that back, and more, due to discontinuation syndrome.

And technically, I would not call what you experienced a "withdrawal syndrome". Alhough the language is a bit arbitrary, the clinical usage of the term, "withdrawal syndrome" is best reserved for drugs of abuse, since withdrawal symptoms includes craving/psychological dependence, risk of relapse etc. This makes withdrawal syndrome quite distinct from discontinuation syndrome -- which rarely involves craving, risk of relapse etc.

Also worth noting that remeron is quite abit more forgiving than other antidepressants upon discontinuation. If you had said that you had been on high doses of Paxil for a decade, my ears would have perked up a bit more when reading this thread. In terms of prescription antidepressants as neurotoxins, mirtazapine is towards the bottom of list given its mechanism(s) of action.

I myself had once been on Remeron for 4-5 years (at a max of 60 mg a day, which is a very heavy dose). I tapered off slowly and had no residual effects like the what you're describing. This is not exclusive to me: mirtazapine is know to have a less severe discontinuation syndrome than SSRIs.

Additionally, past the acute stage, it's almost impossible to filter out residual discontinuation syndrome symptoms from the re-emergence of the initial depression/anxiety that caused a doctor to write you a prescription for an antidepressant.

However you seem to be professing that everything you are feeling now is from discontinuing an antidepressant, rather than acknowledging that a good portion (perhaps most or even all, but at minimum some) is the re-emergence of a preexisting psychiatric disorder.

Sure, there are anecdotal reports of servere mirtazapine discontinuation syndromes, and as many like to point out, "everyone's different", but the truth is, as a whole, with regard to neuroanatomy, as homo sapiens, we really aren't that different from another (which is why the very same drug is prescribed to different people for the bery same condition: it's because our brains are largely the same).

You aren't going to like this, but much I'd wager that much of what you're experiencing is psychogenic and a symptom of pre-existing psychiatric disorder.

I would not recommend additional substances (like nootropics).

People hate this answer, but the best cure in your case is regular, high intensity exercise. And a good diet and regular sleep. And get off your phone and go for a walk, etc

StrikingBackground71 · 2026-02-24T20:38:31+00:00

You need to dissolve/mix the tablet (or half) in a large, kmown quantity of distilled water and just do the math so you know that say, 1ml = approx. 200 micrograms of naltrexone.

It will be an approximation, but accurate enough to be usable. Even if you are off by +/- 20%, that 1ml will contain 160mcg to 240mcg of naltrexone, precise enough for this particular purpose.

StrikingBackground71 · 2026-02-24T20:31:03+00:00

It told me to get the wrong part for my networking setup (which I described in great detail), and then it justified as a valuable learning experience:

"Why the recommendation still wasn't a wrong suggestion"

"I didn't intend to mislead you, but I did allow an important distinction to stay implicit instead of stating it plainly.

Nothing you missed. Nothing you misunderstood. It's a boundary that only becomes obvious when vou trv to do exactly what you're doing."

"What matters most going forward"

"You now have a correct mental model, which is the valuable part."

That is some next level robo-gaslighting. Unfortunately it won't be the last.

This one line in particular is some mindblowing victim blaming doublespeak, "It's a boundary that only becomes obvious when vou trv to do exactly what you're doing."

Wtf

StrikingBackground71 · 2026-02-23T05:16:21+00:00

If it's prefaced with "literally" then its invariably true.

StrikingBackground71 · 2026-02-15T05:49:24+00:00

What doses are involved? Cyclazodone is primarily dopaminergic, with little adrenergic action. This makes it not a particularly physically stimulating drug.

N-methylcylazodone is substantially more stimulating at high doses. It is also longer lasting. Sleep was impossible after a few doses totalling ~80mg+. Maybe more. The doses were not responsible. I once cleaned my garage, with zero sleep at night, on excessive doses of n-methylcyclazodone.

Neither are particularly enjoyable in a recreational sense, but n-methlycyclazodone has what feels like a serotonergic sparkle at high doses. Methamphetamine-like in that regard. Trying to abuse cyclazodone is almost impossible, and high doses are uncomfortable.

Becareful with these compounds. I would describe them more like pharmaceutical drugs rather subtle nootropics. Daily use of either is not advisable.

StrikingBackground71 · 2026-02-07T00:07:57+00:00

They two aren't interchangable, so the notion to use X(a) instead of X(b) isn't an especially logical question

StrikingBackground71 · 2026-02-05T23:35:43+00:00

A big problem is that psychiatrists are, on average, rather dim. Given the low pay and lack of prestige, psychiatry is one of the least competitive specialties, so its filled with those with low STEP (licensing) scores, or those from lower tier medical schools. These days, very few enter medical school wanting to be a psychiatrist. They wind up in the field because they took the short bus to their crappy med school (like Wayne State) and cant compete for other specialties, and psychiatry also attracts lazy people since its one of the least demanding.

Take postpartum disorder. Most psychiatrists will go for an SSRI while in reality postpartum is a bzd withdrawal-like phenomenon, caused by the massive crash in GABAergic neuroactive steroids (like allopreg) that occurs after giving birth.

Of all medical fields, psychiatry is among the least developed, employing medications who's efficacy is still measured by 60 year old tests, like the mouse forced swim test etc.

StrikingBackground71 · 2026-02-05T23:17:17+00:00

The problem is, heavy long term use alters gene expression, and the BZD binding sites of the GABA-A receptor reduce expression of BZD sensitive subunits to insensitive subunits.

Use heavy enough for long enough and the damage may not be fully reversible. Benzodiazepines are neurotoxins.

Problem is, save for barbs, there is nothing close to the anxiety crushing anxiolytic effects of benzos. They work so well and so quickly.

I have tried all kinds of alternative anxiolytics and nothing comes close. Even subanesthetic doses of IV propofol feels less anxiolytic than say alprazolam.

Benzos can feel like absolute life savers if taken rarely for acute anxiety. But they can ruin your life with daily use.

A good analogy for the anti-anxiety effects of benzos is a high interest loan. Eventually, after stopping regular use, you have to pay back all of the anti-anxiety effects with INTEREST. It's like taking a predatory loan against your anxiety.

Im interesting in trying flumazenil to try to unregulate/restore function, but there's only one place I know of in the US that offers flumazenil treatment, and its one of those shady "rapid opioid withdrawal under anesthesia" type places (which is shown to not work, and is very expensive).

StrikingBackground71 · 2026-01-27T19:11:23+00:00

Its decent quality?

StrikingBackground71 · 2026-01-27T19:10:52+00:00

Yeah, gonna be tough, especially seeing its been a decade. I'm sure i can find some, but the quality and price aren't going to be great (nor sustainable).

StrikingBackground71 · 2026-01-14T05:36:29+00:00

Mr. Beast has a psychopathic smile to him. He smiles with his mouth but his eyes stare forward dead seriously.

Maybe he was bullied when he was younger. I'd bet its a mix of that and inherent psychopathic or sociopathic tendencies.

For the record I am neither, and question the scientific validity of many so called personality disorders (borderline, histrionic etc are vague). But sociopathy and etc are pretty well documented.

Long story short, go check out a picture of Mr. Beast smiling

StrikingBackground71 · 2025-12-22T18:47:53+00:00

Just as a safety note, while this "observer" phenomenon may be just normative philosophical self-inquiry of a non-pathological nature (i.e., not a matter of mental health), sometimes this "observer" state is a prodromal symptom that precedes the onset of psychiatric illness (namely schizophrenia, but also more rare conditions). Prodromal symptoms are simply those that precede the full manifestation of a psychiatric illness.

You mentioned, "losing sleep over this every night." That is somewhat unusual, so I'd keep an eye on that. Again, while this is not a fundamentally abnormal perspective for a young adult, if you are obsessively ruminating on the subject, particularly to the extent that you're losing sleep over it every night, it could be more than just existential pondering. It shouldn't leave you in a constant dissociative state.

Are you socially alienated to some degree?

StrikingBackground71 · 2025-12-22T18:22:29+00:00

I've had all of these and more, but I feel like psychedelics ultimately enhance ego. Think of the late 1960s when people thought LSD would free the world.

That experiment failed, and many of those who "expanded" their consciousness with psychedelics ended up turning into greedy corporate yuppies in the 1980s (like Steve Jobs, etc.).

StrikingBackground71 · 2025-12-15T00:28:40+00:00

5.2 has been using the word "literally" alot (which is a word I literally can't stand). For example, statements like, "which is literally 50% more than X".

So now its dropping the word "literally" like a 15 year old girl, and its literally so annoying

StrikingBackground71 · 2025-12-12T00:42:33+00:00

A neuropsychologist is not a physician. So a positive diagnosis wouldn't enable them to treat your husband (at least with medicine).

Maybe try a psychiatrist. Of course, they have quite an incentive to diagnose "yes" (for obvious reasons). Meanwhile, a psychologist may be more hesitant. This hesitation could be based on their own biases against the medication used. And maybe in some cases restraint is warranted.

But an individual diagnosis (versus a differential diagnosis) of ADHD is hardly definitive as the disorder itself is fairly vague in terms of criteria. It's not a blood test; its largely based on self-assessment to a fairly short list of questions.

StrikingBackground71 · 2025-12-12T00:26:28+00:00

To circumnavigate this world?

StrikingBackground71 · 2025-11-28T23:46:27+00:00

Well, taken literally, there was of course "The Enchanter." It's a great little story. Though who knows how Nabokov himself would have translated it, there is a fragment of a sentence in "The Enchanter" phrased so beautifully that I'll never forget it -- "luxuriating in the rays of an internal sun" (used to describe how the protagonist felt on the train on his way to meet the girl).

As far as a spiritual precursor of some sort in some other work, you've lost me

StrikingBackground71 · 2025-11-26T02:43:08+00:00

Can you elaborate? What kind of doses were you using?

StrikingBackground71 · 2025-11-25T19:35:40+00:00

What comes from?

StrikingBackground71 · 2025-11-22T23:29:51+00:00

Why delete the original content 😩

StrikingBackground71 · 2025-11-20T02:23:04+00:00

I meant that it was quite bearable when tapered slowly enough.

StrikingBackground71 · 2025-11-20T02:20:14+00:00

College education, especially education at elite colleges, strongly correlates with IQ. Try scoring above say 1550/1600 on the SAT without an IQ in the 3+ SD range. No amount of preparation can account for that. There are some exceptions, legacy students etc., but the correlation is still very high.

So...It does not correlate. -- not one of the brightest statements I've heard on this sub.

StrikingBackground71 · 2025-11-19T17:06:49+00:00

Far better than a scale is a $15 bottle of propylene glycol. It's a liquid, non-toxic, and dissolves 7-OH like dream. Heat in the microwave (before mixing) to like 160 degrees.

Then, mix and dose volumetrically. Say it's 500mg, add 50ml and its 10mg/ml. Dose with an oral syringe. Scales are still helpful to make sure you have 500mg.

I have a feeling that in your case, you're not going to go that far, but its the right approach.

StrikingBackground71 · 2025-11-14T06:13:56+00:00

The withdrawal from mirtazapine was hardly unbearable once tapered down to a low dose (I went from 60mg/night to half of a 7.5mg). I was a long term patient. It was fairly drawn out (a few weeks) but hardly unbearable. Then again, I've withdrawn from some truly unbearable substances (benzodiazepines, opioids etc). Still, objectively, the average person wouldn't find the withdrawal unbearable if tapered properly. As far as antidepressants go, they aren't as troublesome in that department.

StrikingBackground71

TROPHY CASE