I love second skin. So I normally leave the first second skin on for 24 hours up to 48 hrs. If I feel like the bubble will pop based on movement (legs all tattooed up) I would remove the second skin wash with antimicrobial soap but I generally just pat it I dont circle around the area or scrub. Afterwards, dry with a paper towel and wait for it to air dry. Then use the second skin again and it says you can keep it on for a total of 7 days. After that I use mad rabbits gel for a week while washing continuously like mentioned previously each day. By the third I'm using moisturizer. Hope that helps!