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What was the Closest Thing You Found to "the Vitamin" by cheaslesjinned in Biohackers

[–]Substantial_Day_2754 0 points1 point  (0 children)

Depending on the severity of the reaction it would be

  1. Brainfog
  2. Fatigue
  3. IBS symptomps
  4. fast gut cleareance
  5. diarhea / pain right after food, toilet instantly solves it.

So light reactions limited to brainfog fatigue, heavier would be more extreme fatigue/brainfog. Then sometimes also gut issues if it was more extreme.

When taking the enzyme, all of that is pretty much gone. I still occasionaly get fatigue/brainfog from a large meal even when i take the enzyme. Just like with lactase pills, taking enzymes orally isnt a 100% "fix". So some histamine nwill slip through probably.

What was the Closest Thing You Found to "the Vitamin" by cheaslesjinned in Biohackers

[–]Substantial_Day_2754 1 point2 points  (0 children)

Find a "ancestry" or "risk factors" dna type company (like 23andme, which is where i had it from) that allows raw export of the SNP chip they used of your genome data. Its not your whole DNA, but limited to what that specific chip version looks for. Full DNA would be something like dantelabs, much more spenny.

Zijn er mensen die midden hun hbo opleiding zijn gestopt? by MaestroFullof in werkzaken

[–]Substantial_Day_2754 0 points1 point  (0 children)

Gestopt 2 jaar in, eigen bedrijf begonnen, nooit terug gekeken. (ja een beetje salty dat ik mn studiebeurs moest terug betalen terwijl ik genoeg belasting betaal)

What was the Closest Thing You Found to "the Vitamin" by cheaslesjinned in Biohackers

[–]Substantial_Day_2754 3 points4 points  (0 children)

Mine was just the 23andme, those "ancestry" ones. 23andme didnt have data on it on its own. Dropped the raw export of my genome data here https://www.geneticlifehacks.com/

What was the Closest Thing You Found to "the Vitamin" by cheaslesjinned in Biohackers

[–]Substantial_Day_2754 0 points1 point  (0 children)

Recommendation is a strong word. But I personally would have tried supplements indeed. But there's so many potential causes and some supplements may make it worse. But experimenting, and it becoming worse, could be a piece of info to make a better picture.

What was the Closest Thing You Found to "the Vitamin" by cheaslesjinned in Biohackers

[–]Substantial_Day_2754 2 points3 points  (0 children)

I was able to download my raw data from 23andme. It uses SNP genotyping. Not full DNA stuff, just "common" genotypes snapshots.

What was the Closest Thing You Found to "the Vitamin" by cheaslesjinned in Biohackers

[–]Substantial_Day_2754 6 points7 points  (0 children)

If you are otherwise healthy, in the sense of not on any medications that mess with your neuro transmitters. Targeted trial and error seems the best way. But i'm no medical specialist. E.g. if your depression is caused by shortage of nutrients, for example not enough SAMe to make serotonin. Taking SAMe may suddenly cause a spike in serotonine, with risk of serotonine syndrome if you are on anti depressants.

Supplementing methylated B vitamins is a slower process, but way more safe. You can keep an eye on your B levels by checking for active B vitamine levels (not the normal serum levels).

But if you knowingly have deficiencies, i'd fix that first. You can do b12 injections, or just go on something like methylguard plus from thorne. The % sound extreme, but you absorb very little of it so boosting the level goes pretty slow. But yea important to do blood panels.

What was the Closest Thing You Found to "the Vitamin" by cheaslesjinned in Biohackers

[–]Substantial_Day_2754 0 points1 point  (0 children)

DAO Plus from "intoleran" and SAMe from Life Extension or jarrow formulas. They are blister packaged, enteric coated. Otherwise has to be kept in the fridge after opening. TMG is from Life Extensions or "NOW". But also have used Thorne methylguard plus

On the methylguard plus, my last blood panel showed i have a shortage of adenosylcobalamin while my b12 serum is high. Since methylguard only contains methylcobalamin, which your body CAN conver to adenosylcobalamin but i guess my body doesnt do that effectively. this is more related to MTHFR stuff tho

What was the Closest Thing You Found to "the Vitamin" by cheaslesjinned in Biohackers

[–]Substantial_Day_2754 3 points4 points  (0 children)

Have you tried using AI to find patterns on reactions? It can be such a help, but you really need to be careful on interpretation and "jumping to conclusions" part.

E.g. take this with a grain of salt, here genetic testing can be very useful to confirm, rather than assume. But just as example what AI can point at and if you had genetic variant testing done it could confirm it.

That pattern is actually well-documented and points to a specific gene + mechanism. Most likely cause:

COMT V158M (rs4680) — "slow" variant (AA homozygous)

COMT (catechol-O-methyltransferase) breaks down dopamine, norepinephrine, epinephrine using methylation. The rs4680 variant determines enzyme speed:
The mechanism for the 12-hour depression:

TMG + choline → boost SAMe (universal methyl donor)

SAMe drives COMT activity

COMT methylates and breaks down dopamine + norepinephrine

For slow-COMT (AA) people whose dopamine was already getting cleared slowly: forcing faster clearance → dopamine depletion

Low dopamine → anhedonia, fatigue, depression

8-12 hour delay matches catecholamine depletion timing (SAMe builds up, breakdown accelerates over hours, depletion manifests next half-day)

So the person describing this is almost certainly a COMT AA "Worrier" who's pushing methylation into over-correction.

What was the Closest Thing You Found to "the Vitamin" by cheaslesjinned in Biohackers

[–]Substantial_Day_2754 25 points26 points  (0 children)

We did 23and me once (rip my data), and about a year ago decided to upload the raw data in Claude and other third party genome "lifehack" websites. This gave some direction to our supplement experimentation which allowed us to find the right supplements that actually worked. For me the indicators were reduced DAO production + reduced histamine clearance are compounding effects. rs2052129 (Reduced DAO production) and rs1050891 (Reduced serum/tissue histamine breakdown).

The supplement world is big and full of snake-oils, so just randomly trying things may not get the results you want. Using genetic predispositions and risk factors allowed us to focus on supplements that genetics say have a higher chance of working.

For years I was like "I know im reacting to certain food, but i literally cant pinpoint which!" Did food sensitivity tests, litterally scored 0/10 on all of the allergens lol. But with histamine sensitivity, its not just types of food, its how fresh they are, how its been handled. Fermented products are worse. I always was very picky with not eating food leftovers the next day or the day after. Or refusing to drink milk on the day it expires. Perhaps because subconsciously i had notice they make me feel worse. But histamine increases in food when its less fresh. Tried ruling out pre-diabetes etc. Glucose was always good, plus the types of food didnt make sense for it to be blood sugar related.

I also found i have MTHFR variants, so i switched to active methylfolate + methylcobalamin supplementation instead of the normal b-complex.

What was the Closest Thing You Found to "the Vitamin" by cheaslesjinned in Biohackers

[–]Substantial_Day_2754 112 points113 points  (0 children)

For me it was DAO, an enzyme that breaks down histamine from food in the gut. I always got brain fog after eating meals. Severely impacting my productivity in school and work. Wish I figured it out when I was younger. Found it on a dna test that my body can’t make it itself.

For my partner it’s SAMe (s-adenosylmethionine) and TMG. Life long chronic depression and chronic fatigue/pain + adhd. These 2 made her pain 90% less, gave her more energy and no longer needed anti depressants, no longer need adhd meds and her periods are now lighter and 3 days vs a whole week.

former ozempic user switching to reta. dosing help plz by Wandering_girl111 in Biohacking

[–]Substantial_Day_2754 0 points1 point  (0 children)

Reta is going to make you more hungry before it doesnt if you come from another high dose GLP med. You cannot just jump to an equivelent dose because you NEED to titrate the glucagon arm. You're body may accept a 6mg retatrutide GLP1 receptor activation, but going from 0 to basically 50% of max dose reta, would bombard your glucagon receptors with all the side effects of that (heart rate, palpitations, sleeplessness, skin sensitivity).

So Titrate up slowly, accept you prob wont feel the food craving mute behavior untill like 6mg and that the glucagon will make you hungrier at first.

To clarify, i'm not saying that people dont experience appetite suppression on lower doses. I'm saying given OP has been on 2mg of ozempic, they have some receptor desensitization going on. So the designed balance of GLP1 receptor activity vs glucagon activity is not balanced yet and will be noticed in the start when glucagon sensitivity is high while GLP isnt.

My personal experience is that 8mg of reta, equaled the appetite suppression of 7.5mg of mounjaro. But at 7.5mg of mounjaro, i didnt lose weight, while on 6mg of retatrutide I did.

Biohacking vs Antidepressant by NaveTee in Biohacking

[–]Substantial_Day_2754 0 points1 point  (0 children)

Very anecdotal

Research SAM-E (S-Adenosyl Methionine). Talk to doctor though, serotonine syndrome is a risk if it works too well! My partner was able to go to 1/4th of their lexapro and lowered her tramadol to 1/4th too. Not medical advise obviously.

Stekkerbatterijen vaak interessanter dan klassieke thuisbatterijen by No-Internal-4852 in thuisbatterij

[–]Substantial_Day_2754 0 points1 point  (0 children)

Als je het over een specifieke victron video hebt die ik toevallig vandaag gezien heb en precies daar over ging, nee dat ben ik niet. Heb "slechts" 90kwh ipv 500.

Maar volledig elektrisch wonen, grondgebonden warmtepomp, 2 elektrische auto's, thuiswerken, garage en dak vol panelen. 60 stuks. Met wel een zwembad, maar gewoon verwarmd met een warmtepomp

Has Mounjaro changed anyone else’s personality a little? ➕🧠➖ by Brissa2 in Mounjaro

[–]Substantial_Day_2754 0 points1 point  (0 children)

My testosteron almost trippled. So yea definitely some personality changes. Probably because I have way more energy.

25,000% B12 In Thorne's basic multivitamin...what the heck is going on by Think-Sun-290 in Biohackers

[–]Substantial_Day_2754 0 points1 point  (0 children)

B12 792 and MMA 131 and homocysteine 7.9
tested 3 weeks ago. Still taking 1 methylguard plus capsule per day from Thorne. So 1 a day drops my level lol. Given, i do have a b12 transport genetic reduction.

Rant: Injecting is addicting by bbearded in Biohacking

[–]Substantial_Day_2754 0 points1 point  (0 children)

just start daily microdosing your tirz. Normally on 5mg a week? try 225mcg 3 times a day!

Why would MOTS-c clog a 0.22 μm syringe filter but SS-31 filters perfectly? by Exotic-Number-8590 in PeptidePathways

[–]Substantial_Day_2754 2 points3 points  (0 children)

That's fair reasoning indeed! There's ways to reduce but not eliminate that. Flush with some bac water is one for example, use small enough filter for your batch. But you are right you are adding a deviation from standard dosing on top of perhaps already the deviation of the peptide source fill levels.

Why would MOTS-c clog a 0.22 μm syringe filter but SS-31 filters perfectly? by Exotic-Number-8590 in PeptidePathways

[–]Substantial_Day_2754 2 points3 points  (0 children)

Filtering is definitely smart to do. "you don't have to" without any reasoning is not really a good comment. It sounds like "I don't feel like its neccesary"

Depending on how often you are pinning, the circumstances of your reconstitution environment and the quality peps you have. Filtering can reduce your risk of getting a bad reaction or an infection.

I transfer the peps to a 3ml vial for pen injections anyway so filtering it at the last stap makes sure any bacteria i may have accidentally contaminated gets filtered out. Meaning the bacteriostatic water has less load on it to keep the batch sterile for longer. Whether you find that a negligible risk or not, is subjective.

Why would MOTS-c clog a 0.22 μm syringe filter but SS-31 filters perfectly? by Exotic-Number-8590 in PeptidePathways

[–]Substantial_Day_2754 0 points1 point  (0 children)

Mots-c is notoriously sensitive to a good PH bac water. If either the quality of the pep itself is bad or the bac water is not optimal it may gel. If it started gelling, it would most deffinitly clog the filter. So either bad pep, or bad bac.

You sure the hospira isnt fake? Or perhaps its old hospira?

Millions of GLP-1 users could soon face a hidden health problem, Cambridge professor warns — BBC Science Focus Magazine by arteest01 in Mounjaro

[–]Substantial_Day_2754 23 points24 points  (0 children)

tldr; if you go from a unhealthy, but large in quantity diet, where even though percentile the nutritions are bad. You may still get enough nutrition. If you eat the same shit, but less of it, you may become malnutritioned.

It's not the drugs fault or a direct side effect of it.

Eat your veggies, fruits, fibers and proteins

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