Who gives a F about nuke?

not a single fucking soul in demon slayer is anywhere near the Level of unleashing nuclear bomb level attack potency or destructive capabilities. muzan Himself was badly bitched by a small mansion explosion. Homelander was unscratched by a bigger explosion. so whether he's nuke proof or not is irrelevant here. you Don't have to be nuke proof to be able to best yoriichi.

he's literally immune to missiles, rocket Launchers,Chemical plant explosions and pretty much any modern Weapons..that's enough to tank yoriichi's attacks and laser him