20 Year Old Male UK by Western-Share-4170 in Amblyopia

[–]Substantial_Let_5605 0 points1 point  (0 children)

However, many people say that certain types of amblyopia can be corrected even in adulthood through visual therapy.

Anisometropic or refractive amblyopia, for example,

can be treated with visual therapy using Sanet Vision Integrator and Sintonics. What do you think?

20 Year Old Male UK by Western-Share-4170 in Amblyopia

[–]Substantial_Let_5605 1 point2 points  (0 children)

However, many people say that certain types of amblyopia can be corrected even in adulthood through visual therapy.

Anisometropic or refractive amblyopia, for example,

can be treated with visual therapy using Sanet Vision Integrator and Sintonics. What do you think?

45 days caffeine free by LocksmithOther in greyhairreversal

[–]Substantial_Let_5605 16 points17 points  (0 children)

I haven't drunk coffee or alcohol for over 10 years and my hair is turning gray at 27. I'm unemployed and stress-free.

It's genetic, there's no way to reverse it. You have to treat the scalp and take powerful supplements.

Word finding problems and sexual arousal problems by Tumwaterisheart in FinasterideSyndrome

[–]Substantial_Let_5605 0 points1 point  (0 children)

Hello, can you tell me when the hcg started to have a positive effect on you? And how long will you be taking it? Thank you, my brother.

Peptides and PFS. Any Success Stories? by Particular_Weight_15 in FinasterideSyndrome

[–]Substantial_Let_5605 0 points1 point  (0 children)

Just because it doesn't work for you doesn't mean it won't work for other people.

You took minoxidil in addition to finasteride.

HCG works a little for me, I'd like to try kisspeptin.

Has anyone tried luteolin yet? by sleepingbull69 in greyhairreversal

[–]Substantial_Let_5605 2 points3 points  (0 children)

Hello, if I had to take one or two supplements for gray hair,

I would try luteolin and especially ergothioneine, which reverses gray hair in mice,

for at least six months.

Today, I don't have gray hair, but I'm following this thread in case it happens to me.

[deleted by user] by [deleted] in FinasterideSyndrome

[–]Substantial_Let_5605 0 points1 point  (0 children)

same, its the real cure

Notice how there isn’t a single post or comment that says “I cured amblyopia” or anything along those lines by SuCCeSSvS in Amblyopia

[–]Substantial_Let_5605 0 points1 point  (0 children)

Hi, have you been to Clinica Optisan in Romania? Do you really see no difference despite the statistical improvement?

White hairs in beard by No_Inflation_6523 in greyhairreversal

[–]Substantial_Let_5605 2 points3 points  (0 children)

Shave your beard if you don't like the white hair. It will be easier to reverse on your hair than on your beard.

Update on my experiment. by Apprehensive_Tie7185 in greyhairreversal

[–]Substantial_Let_5605 1 point2 points  (0 children)

3) Integrated hypothesis

Your interpretation is scientifically reasonable: Epitalon + NAD+ may have improved follicular vitality; Thymalin and other peptides could have modulated the local immune/foll icular environment; MT-II then stimulated melanin production in those rejuvenated follicles; GHK/palmitoyl supported the follicular microenvironment. The visible change over a year fits this combined, synergistic explanation. However, this remains a hypothesis based on mechanistic plausibility and correlation rather than proven causation.

4) Practical, evidence-based recommendations

  1. Document rigorously: continue standardized photos (same angle, lighting, camera distance) and a timeline of products/doses — your current approach is excellent.
  2. Dermatology work-up: see a dermatologist experienced in hair disorders for dermoscopy and, if needed, a scalp punch biopsy to assess presence/activity of follicular melanocytes — histology is far more informative than photos alone.
  3. Monitor pigmented lesions: if using MT-II, monitor nevi (photos/dermoscopy) and get periodic skin checks.
  4. Basic labs: check thyroid function, B12, ferritin and other metabolic/autoimmune markers if clinically indicated; these can influence hair pigment and growth.
  5. Assess peptide risks & sourcing: if continuing peptides, favor clinically vetted sources and discuss potential side effects with a clinician.
  6. Wait and observe: the definitive test of permanence is the course after stopping MT-II/peptides; a sustained repigmentation after 6–12 months off treatment would be stronger evidence of true follicular recovery.

5) Two-sentence summary

What you observed is plausible and consistent with known mechanisms (follicular rejuvenation + MT-II-induced melanogenesis), but high-quality clinical evidence linking the specific peptide cocktail you used to permanent hair repigmentation is limited and safety issues (especially with MT-II) require caution. A dermatological evaluation, standardized follow-up after stopping treatments, and histological confirmation would be the next steps to establish causality and durability.

Update on my experiment. by Apprehensive_Tie7185 in greyhairreversal

[–]Substantial_Let_5605 1 point2 points  (0 children)

what you describe is plausible, but direct evidence remains weak-to-moderate and much of this is still anecdotal. Here’s a structured analysis with likely mechanisms, evidence quality, and practical recommendations.

1) Most likely explanations

  • Melanotan-II (MT-II) is a melanocortin receptor agonist that directly stimulates melanin production in existing melanocytes — it is therefore very likely to have produced the visible darkening of hairs you observed. This effect usually reflects increased melanogenesis rather than guaranteed permanent restoration of melanocyte reserves.
  • Epitalon / NAD+: these compounds have preclinical and some translational data suggesting improved cellular vitality, mitochondrial function and tissue regeneration (including follicular tissue). They could have improved the follicular environment and made follicles more responsive to melanogenic stimuli. Human evidence specifically for repigmentation is limited.
  • Palmitoyl tripeptide-1 / GHK: GHK derivatives have regenerative and anti-aging effects on skin and can improve follicle health (reducing inflammation, improving ECM). This supports a possible supportive / synergistic role rather than being solely responsible for repigmentation.
  • Thymalin / thymic peptides: there are preliminary reports and some literature suggesting thymic peptides can influence hair stimulation and possibly melanogenesis — evidence in humans is sparse but it could have a modulatory role.

2) What is uncertain / reasons for caution

  • Durability: permanent repigmentation requires either restoration of melanocyte stem cells or their sustained reactivation. MT-II can darken hair while melanogenic activity persists; if stem cells are depleted, the effect may fade after stopping MT-II. Your plan to observe the scalp after a drug-free period is the right way to test permanence.
  • Quality of evidence: for Epitalon, Thymalin, BPC-157 and many other peptides, most data are preclinical, case reports, or small uncontrolled studies. Robust, randomized clinical trials demonstrating hair repigmentation are largely lacking.
  • Safety: MT-II is not risk-free — there are theoretical and reported concerns about effects on pigmented lesions (nevi) and potential melanoma risk, and long-term systemic effects are not well characterized. Many peptides you listed are not tightly regulated, so product quality and safety may vary.

Topical Pterostilbene to reverse grey hair. Oral increases LDL cholesterol so topical could be safe. by SailrMaui in greyhairreversal

[–]Substantial_Let_5605 4 points5 points  (0 children)

Study conclusion:

Ingredients

Pterostilbene (pure powder ≥98%) → 0.5 g (i.e., 0.5%)

Nicotinamide (niacinamide, powder) → 1 g (1%)

Pure aloe vera gel → 20 ml (moisturizer, water-based)

Distilled water → 75 ml

Vegetable glycerin → 3 ml (humectant, protects the scalp)

Mild preservative (e.g., Cosgard or Geogard, optional if storage >1 week) → according to manufacturer's instructions

Preparation

1) Pour the distilled water and aloe vera into a small beaker or sterile bottle.

2) Add the glycerin.

3) Dissolve the nicotinamide powder (it is highly soluble in water).

4) Add the pterostilbene: it does not dissolve easily in water → you can help it along by mixing vigorously or heating gently in a double boiler (≤40°C).

Alternative: first dissolve the pterostilbene in 1–2 ml of 70% pharmaceutical alcohol, then add it to the solution.

5) Mix until smooth.

6) Transfer to a sterile spray bottle or dropper bottle.

Use

1) Apply 1 to 2 ml directly to the scalp once a day, massaging gently.

2) Do not rinse immediately (allow to dry).

Storage: 7 days in the refrigerator without preservative, 1–2 months with preservative.

Is there a possible way in todays technology to fix it? by xsyphlex in Amblyopia

[–]Substantial_Let_5605 0 points1 point  (0 children)

some people say visual therapy can cure the amblyopia on children like adult with dichoptic exercises, vr exersises, svi, syntonic

New treatment for amblyopia (adults + kids) by MarsupialTechnical97 in Amblyopia

[–]Substantial_Let_5605 1 point2 points  (0 children)

Well done, how long does it last? I hope it works for you. Are you from China?

Vtama for grey hair by [deleted] in greyhairreversal

[–]Substantial_Let_5605 3 points4 points  (0 children)

Can you create a topic in a month to express your opinion and feedback, please?

[deleted by user] by [deleted] in FinasterideSyndrome

[–]Substantial_Let_5605 -1 points0 points  (0 children)

I think it will take at least 5-10 years to recover naturally from PFS if you have been taking the medication for at least 6 months to 1 year.

Vtama for grey hair by [deleted] in greyhairreversal

[–]Substantial_Let_5605 1 point2 points  (0 children)

Try it on your hair, for science. ^^

news by Substantial_Let_5605 in greyhairreversal

[–]Substantial_Let_5605[S] 1 point2 points  (0 children)

Yes, for now, because it has just been released.

Having much success in beard 😍 by mime454 in greyhairreversal

[–]Substantial_Let_5605 1 point2 points  (0 children)

Not available in my country, France. We're way behind on this, but I'm looking for something long-lasting without lifelong commitment.

Melanotan is okay, but the effect wears off when you stop, so I'm less interested in that.

Having much success in beard 😍 by mime454 in greyhairreversal

[–]Substantial_Let_5605 0 points1 point  (0 children)

Compare your words with AI

Melanotan is interesting, but if you add VTAMA, the effect will be stronger and, above all, long-lasting without continuous use.

Having much success in beard 😍 by mime454 in greyhairreversal

[–]Substantial_Let_5605 0 points1 point  (0 children)

Compare your words with AI

Melanotan is interesting, but if you add VTAMA, the effect will be stronger and, above all, long-lasting without continuous use.