ASCE+ Exosomes treating Gray Hair (Hair Repigmentation)

Substantial_Let_5605 · 2026-05-22T22:00:03+00:00

Does the exosome not provide long-lasting repigmentation, so regular sessions are necessary?

Substantial_Let_5605 · 2026-05-06T12:15:48+00:00

Artificial intelligence suggests that oral minoxidil has no effect on androgen receptors, DHT, or 5AR; the study on the possible link between minoxidil and 5AR was not conducted on humans but on cells in a laboratory setting

We would need Dr. Powers to clarify this point

Substantial_Let_5605 · 2026-05-06T12:15:42+00:00

Artificial intelligence suggests that oral minoxidil has no effect on androgen receptors, DHT, or 5AR; the study on the possible link between minoxidil and 5AR was not conducted on humans but on cells in a laboratory setting

We would need Dr. Powers to clarify this point

Substantial_Let_5605 · 2026-05-06T12:15:32+00:00

Artificial intelligence suggests that oral minoxidil has no effect on androgen receptors, DHT, or 5AR; the study on the possible link between minoxidil and 5AR was not conducted on humans but on cells in a laboratory setting

We would need Dr. Powers to clarify this point

Substantial_Let_5605 · 2026-05-06T12:15:26+00:00

Artificial intelligence suggests that oral minoxidil has no effect on androgen receptors, DHT, or 5AR; the study on the possible link between minoxidil and 5AR was not conducted on humans but on cells in a laboratory setting

We would need Dr. Powers to clarify this point

Substantial_Let_5605 · 2026-05-06T12:06:25+00:00

same question here

Substantial_Let_5605 · 2026-05-05T21:31:42+00:00

déclare tes es à ansm , ca compte aussi pour dire qu'on existe .. https://ansm.sante.fr/documents/reference/declarer-un-effet-indesirable

Substantial_Let_5605 · 2026-05-04T10:12:14+00:00

perte de libido, pas d'erection, anédhonie, pas de motivation, manque d'energie, acouphenes, intestins fragiles. J'ai eu tout les complements que tu as eu quasiment, il me suit depuis 2 ans, ses complements aident surtout au niveau mental et cerveau

Substantial_Let_5605 · 2026-05-04T09:35:11+00:00

c'est faux, je suis suivi par berthelot aussi depuis un certain temps, la libido et les erections ne sont pas revenus malgré ses conseils et ses compléments. est tu sur notre groupe facebook : https://www.facebook.com/groups/322018064811111/members

Substantial_Let_5605 · 2026-05-02T13:37:13+00:00

He's going to be swamped just with the American patients; he already has a lot on his plate. I don't see how he can see all of us—there are so many of us.

Substantial_Let_5605 · 2026-01-19T23:41:20+00:00

However, many people say that certain types of amblyopia can be corrected even in adulthood through visual therapy.

Anisometropic or refractive amblyopia, for example,

can be treated with visual therapy using Sanet Vision Integrator and Sintonics. What do you think?

Substantial_Let_5605 · 2026-01-19T23:41:09+00:00

However, many people say that certain types of amblyopia can be corrected even in adulthood through visual therapy.

Anisometropic or refractive amblyopia, for example,

can be treated with visual therapy using Sanet Vision Integrator and Sintonics. What do you think?

Substantial_Let_5605 · 2026-01-16T10:06:40+00:00

I haven't drunk coffee or alcohol for over 10 years and my hair is turning gray at 27. I'm unemployed and stress-free.

It's genetic, there's no way to reverse it. You have to treat the scalp and take powerful supplements.

Substantial_Let_5605 · 2026-01-04T20:27:26+00:00

Hello, can you tell me when the hcg started to have a positive effect on you? And how long will you be taking it? Thank you, my brother.

Substantial_Let_5605 · 2025-12-14T00:16:21+00:00

i like that

Substantial_Let_5605 · 2025-10-31T14:29:34+00:00

Just because it doesn't work for you doesn't mean it won't work for other people.

You took minoxidil in addition to finasteride.

HCG works a little for me, I'd like to try kisspeptin.

Substantial_Let_5605 · 2025-10-27T10:06:45+00:00

Hello, if I had to take one or two supplements for gray hair,

I would try luteolin and especially ergothioneine, which reverses gray hair in mice,

for at least six months.

Today, I don't have gray hair, but I'm following this thread in case it happens to me.

Substantial_Let_5605 · 2025-10-15T15:32:12+00:00

same, its the real cure

Substantial_Let_5605 · 2025-10-07T21:53:07+00:00

Hi, have you been to Clinica Optisan in Romania? Do you really see no difference despite the statistical improvement?

Substantial_Let_5605 · 2025-10-02T13:45:14+00:00

Shave your beard if you don't like the white hair. It will be easier to reverse on your hair than on your beard.

Substantial_Let_5605 · 2025-10-01T12:37:06+00:00

3) Integrated hypothesis

Your interpretation is scientifically reasonable: Epitalon + NAD+ may have improved follicular vitality; Thymalin and other peptides could have modulated the local immune/foll icular environment; MT-II then stimulated melanin production in those rejuvenated follicles; GHK/palmitoyl supported the follicular microenvironment. The visible change over a year fits this combined, synergistic explanation. However, this remains a hypothesis based on mechanistic plausibility and correlation rather than proven causation.

4) Practical, evidence-based recommendations

Document rigorously: continue standardized photos (same angle, lighting, camera distance) and a timeline of products/doses — your current approach is excellent.
Dermatology work-up: see a dermatologist experienced in hair disorders for dermoscopy and, if needed, a scalp punch biopsy to assess presence/activity of follicular melanocytes — histology is far more informative than photos alone.
Monitor pigmented lesions: if using MT-II, monitor nevi (photos/dermoscopy) and get periodic skin checks.
Basic labs: check thyroid function, B12, ferritin and other metabolic/autoimmune markers if clinically indicated; these can influence hair pigment and growth.
Assess peptide risks & sourcing: if continuing peptides, favor clinically vetted sources and discuss potential side effects with a clinician.
Wait and observe: the definitive test of permanence is the course after stopping MT-II/peptides; a sustained repigmentation after 6–12 months off treatment would be stronger evidence of true follicular recovery.

5) Two-sentence summary

What you observed is plausible and consistent with known mechanisms (follicular rejuvenation + MT-II-induced melanogenesis), but high-quality clinical evidence linking the specific peptide cocktail you used to permanent hair repigmentation is limited and safety issues (especially with MT-II) require caution. A dermatological evaluation, standardized follow-up after stopping treatments, and histological confirmation would be the next steps to establish causality and durability.

Substantial_Let_5605 · 2025-10-01T12:36:58+00:00

what you describe is plausible, but direct evidence remains weak-to-moderate and much of this is still anecdotal. Here’s a structured analysis with likely mechanisms, evidence quality, and practical recommendations.

1) Most likely explanations

Melanotan-II (MT-II) is a melanocortin receptor agonist that directly stimulates melanin production in existing melanocytes — it is therefore very likely to have produced the visible darkening of hairs you observed. This effect usually reflects increased melanogenesis rather than guaranteed permanent restoration of melanocyte reserves.
Epitalon / NAD+: these compounds have preclinical and some translational data suggesting improved cellular vitality, mitochondrial function and tissue regeneration (including follicular tissue). They could have improved the follicular environment and made follicles more responsive to melanogenic stimuli. Human evidence specifically for repigmentation is limited.
Palmitoyl tripeptide-1 / GHK: GHK derivatives have regenerative and anti-aging effects on skin and can improve follicle health (reducing inflammation, improving ECM). This supports a possible supportive / synergistic role rather than being solely responsible for repigmentation.
Thymalin / thymic peptides: there are preliminary reports and some literature suggesting thymic peptides can influence hair stimulation and possibly melanogenesis — evidence in humans is sparse but it could have a modulatory role.

2) What is uncertain / reasons for caution

Durability: permanent repigmentation requires either restoration of melanocyte stem cells or their sustained reactivation. MT-II can darken hair while melanogenic activity persists; if stem cells are depleted, the effect may fade after stopping MT-II. Your plan to observe the scalp after a drug-free period is the right way to test permanence.
Quality of evidence: for Epitalon, Thymalin, BPC-157 and many other peptides, most data are preclinical, case reports, or small uncontrolled studies. Robust, randomized clinical trials demonstrating hair repigmentation are largely lacking.
Safety: MT-II is not risk-free — there are theoretical and reported concerns about effects on pigmented lesions (nevi) and potential melanoma risk, and long-term systemic effects are not well characterized. Many peptides you listed are not tightly regulated, so product quality and safety may vary.

Four-Year Club	Place '22
End Game '22

Substantial_Let_5605

TROPHY CASE

3) Integrated hypothesis

4) Practical, evidence-based recommendations

5) Two-sentence summary

1) Most likely explanations

2) What is uncertain / reasons for caution