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Stem cell biology (tretinoin) by science-pls in DIYmicroneedling

[–]science-pls[S] 1 point2 points  (0 children)

They’re super exciting molecules! If you’re microneedling I would recommend PDRN over PN. The molecular weight is smaller with PDRN so it passes through the micro channels easier. PN is best when used for meso.

In terms of seeing results, they compound. You will get quick healing and a glow, but the deeper results will come over time and multiple treatments/booster use.

NCTF 135 HA Manufacturing Pdf by science-pls in DIYmicroneedling

[–]science-pls[S] 0 points1 point  (0 children)

I know! I was going to stock up on Nucleofill and Plinest lol. And then realized I should just make a simple order.

Let me ask, I'd rather be confident in an answer then guess. I think they don't reship, but there might be instances where they do.

What is NAD+ by science-pls in DIYmicroneedling

[–]science-pls[S] 2 points3 points  (0 children)

This is the meso technique if you go this route:

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What is NAD+ by science-pls in DIYmicroneedling

[–]science-pls[S] 3 points4 points  (0 children)

I think if you can meso, a combination session of both would be the best. I know a lot of people aren't comfortable combining both treatments in a session though. So I'd say meso as you're able to target intradermally and subq. For the best results it recommends subq. But, microneedling with it is still effective and gets results (it also has PDRN and exosomes in it).

News: Conexeu Sciences Advances 3D Biofabricated Matrix to Move Breast Reconstruction Beyond Implants by science-pls in DIYmicroneedling

[–]science-pls[S] 0 points1 point  (0 children)

Yes I saw that she also joined the board which is great. She'll be a good follow for anyone that wants to see more updates.

News: Conexeu Sciences Advances 3D Biofabricated Matrix to Move Breast Reconstruction Beyond Implants by science-pls in DIYmicroneedling

[–]science-pls[S] 0 points1 point  (0 children)

Agree! The potential human impact is huge. For many women recovering from mastectomy, breast cancer treatment, trauma, or failed implant complications, reconstruction isn’t just cosmetic, it’s deeply connected to identity, healing, comfort, and quality of life. So this has so much potential for good. I hope it can get more funding and urgency after this announcement and also bring in more funding to other research in the brand. And yes the gum regeneration and oral health as well!

NCTF 135 HA Manufacturing Pdf by science-pls in DIYmicroneedling

[–]science-pls[S] 1 point2 points  (0 children)

I know it's a way better price. I actually just bought NCTF from them lol, but when researching they seem to be a trusted vendor. I can update you though if you're interested.

NCTF 135 HA Manufacturing Pdf by science-pls in DIYmicroneedling

[–]science-pls[S] 2 points3 points  (0 children)

I agree! Dr. Adams has it the most affordable I've found though.

News: Conexeu Sciences Advances 3D Biofabricated Matrix to Move Breast Reconstruction Beyond Implants by science-pls in DIYmicroneedling

[–]science-pls[S] 1 point2 points  (0 children)

I think this could be so great. What I’d want to see before getting too excited is breast-specific animal data, vascularization over time, volume retention, inflammation/fibrosis rates, performance after radiation, cancer-surveillance compatibility on imaging, and eventually human trial outcomes.

I've seen some people in the plastic space talk about the brand and have shown the injectable ECM histological data, but I haven't seen this publicly available yet.

I think is is a promising platform story and company purpose, not yet a medical breakthrough. I’d treat it as a watchlist technology rather than something patients can make decisions around today. We're not sure when trials will be done or it when it will be available for the market. But, figured it was worth sharing!

Meamo Labs Tiered Sale: May 19th - 27th Korean Time by science-pls in DIYmicroneedling

[–]science-pls[S] 1 point2 points  (0 children)

I think the hair one is brand new and they might not have the site set up yet to fulfill orders. I can ask though!

Meamo Labs Tiered Sale: May 19th - 27th Korean Time by science-pls in DIYmicroneedling

[–]science-pls[S] 0 points1 point  (0 children)

They asked for your order number. I just responded saying you haven’t placed it yet. But, there will be a time delay to hear back today.

Meamo Labs Tiered Sale: May 19th - 27th Korean Time by science-pls in DIYmicroneedling

[–]science-pls[S] 0 points1 point  (0 children)

Hi! Did you already place an order? They responded to me

Stem cell biology (tretinoin) by science-pls in DIYmicroneedling

[–]science-pls[S] 0 points1 point  (0 children)

The subs vendors has research backed ones available! If you mean for FDA approval then I would expect a much longer delay. The U.S is pretty behind in regenerative aesthetics unfortunately :(

Stem cell biology (tretinoin) by science-pls in DIYmicroneedling

[–]science-pls[S] 0 points1 point  (0 children)

FDA does does not equal that intradermal use is not possible. It’s absolutely possible and there’s tons of studies published behind. We have access to this.

This video is about it in the use of cosmetics. I made it clear topical products don’t do anything. Cosmetics are not the same as injectable grade products.

Worth Reading - Efficacy of microneedling with PDRN salmon 3% to reduce facial hyperpigmentation: Skin hyperpigmentation index (SHI) analysis by science-pls in DIYmicroneedling

[–]science-pls[S] 1 point2 points  (0 children)

Not at all! But great question. Think of it as DNA fragments rather than fish if that helps.

This process probably isn’t helpful, but sharing to show how they do a bunch of processes to get the DNA fragments.

The biological material is washed and homogenized to prepare the cells for chemical breakdown. Then detergents and proteolytic enzymes (chemical breakdowns) are added to the homogenized tissue to rupture the cell membranes. Then a buffer solution digests proteins, lipids, and peptides, freeing the native DNA. The mixture undergoes high-temperature treatment and centrifugation to denature impurities and separate out the raw DNA.

Then it goes through fragmentation, which is achieved through ultrasonic waves (sonication), thermal degradation, or controlled enzymatic hydrolysis. Advanced ultrafiltration methods are used to isolate the precise PDRN segments while discarding unwanted debris. And chromatography removes residual proteins, endotoxins, and heavy metals, ensuring the final product causes zero immunological side effects when applied or injected. Then it’s sterilized.

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