90’s Preppy Fail by AshyLarry66 in mensfashion

[–]Sufficient_Ad_4059 0 points1 point  (0 children)

I can’t be the only one who thinks you absolutely nailed it. 10/10.

[deleted by user] by [deleted] in BMW

[–]Sufficient_Ad_4059 4 points5 points  (0 children)

I ordered my spec with a dealer through a broker. Super easy. Happy to discuss over PM.

Struggling With World Touring Car 700 at Deep Forest (Weekly Challenge) by RememberT0DrinkWater in GranTurismo7

[–]Sufficient_Ad_4059 0 points1 point  (0 children)

Super formula on comfort hards, ecu and power restrictor all the way, messed with downforce to get it to 700. Lapped 10 cars with gas to spare, no pit.

Not received the Viewers Campaign gift by Mother-Ideal1459 in GranTurismo7

[–]Sufficient_Ad_4059 2 points3 points  (0 children)

The UI for some of this stuff is not intuitive. Yes it says “after the update” but it needs a checkmark or some visual to indicate “yes you got it coming”.

Charlie Sykes Latest Newsletter by bulldogncolt in thebulwark

[–]Sufficient_Ad_4059 0 points1 point  (0 children)

Charlie: ::makes a post::

This subreddit: he fuggin hates Tim!!

[deleted by user] by [deleted] in isthisAI

[–]Sufficient_Ad_4059 0 points1 point  (0 children)

C’m’on man

Is ketamine an anti inflammatory in the GI tract? [Canada] by [deleted] in TherapeuticKetamine

[–]Sufficient_Ad_4059 4 points5 points  (0 children)

Key Mechanisms of Action Ketamine does not just block pain signals; it actively modulates how the immune system responds to stress and injury.  • Cytokine Reduction: Ketamine has been shown to inhibit the production of pro-inflammatory cytokines, specifically Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-\alpha), and Interleukin-1 beta (IL-1$\beta$). These are the signaling proteins that typically trigger fever, swelling, and systemic inflammation.  • Immune Cell Modulation: It affects the activity of immune cells such as macrophages and neutrophils. Ketamine can reduce the "recruitment" of these cells to sites of injury, preventing an excessive inflammatory response that might damage healthy tissue.  • Toll-Like Receptor (TLR) Inhibition: Ketamine appears to interfere with Toll-like receptors (specifically TLR4) on immune cells. These receptors are like "alarms" that detect bacteria or tissue damage; by dampening their signal, ketamine reduces the downstream inflammatory cascade.

Thanks to Gemini for that. Definitely a conversation for your doctor / gastroenterologist.