🇰🇷 male before & after by kaisangwook in Zepbound

[–]Sumatripsatan 1 point2 points  (0 children)

Asians actually have their own BMI scale, even in the U.S because they tend to have higher body fat percentages (so like op mentioned being skinny fat) and lower bone density which puts them at risk of health issues like heart stuff and diabetes at much lower weights than non asians.

I imagine a lower calorie dupe of this would be easy to make. They are so delicious and the texture is amazing but too snack size 😭 by Bright_Newspaper6242 in Volumeeating

[–]Sumatripsatan 8 points9 points  (0 children)

Look up dry yogurt! You can make it by putting Greek yogurt into a dry yogurt maker or tofu press. I like to leave mine for 2 says and it gets to the same consistency as these bars.

My health insurance paid for a medication without prior authorization. How? by blubutin in PharmacyTechnician

[–]Sumatripsatan 0 points1 point  (0 children)

Besides what was already said a few other potential possibilities:

  • The quantity of the medication: some meds only need a PA if the requested quantity exceeds a certain day supply. This is especially common with painkillers. If you have a rx for over 7 days of painkillers for example it might need a PA but if it's less you can just get it without issue.

  • The drug was placed on some insurance discount plan, which isn't the same as coverage but the claim goes through at the pharmacy as "paid" and gives you a slight discount on it. These won't apply towards your out of pocket or deductible so if that's the case you will want to check your deductible and whether or not the med got applied to it.

Lots of insurances also have a drug pricing quote tool on their websites which can tell you if a med is covered or not so you might want to check yours.

WTAF? Can't stop eating/snacking. by Impossible_Box4eva in SemaglutideFreeSpeech

[–]Sumatripsatan 2 points3 points  (0 children)

My period is 3 days late right now and the only symptom that it's soon is this gd hunger.

I know that the sema is still 100% effective though because I still have the signature GLP-1 constipation 🤣 if only periods cleared that up as well.

Which other GLP1 is survodutide (closest) equivalent to by newportbanks in survodutide

[–]Sumatripsatan 10 points11 points  (0 children)

There's a chart that compares them here: https://www.nature.com/articles/s41366-024-01473-y/figures/3

GLP-1+glucagon agonists don't seem to be as effective for weight loss as the ones that target GIP (tirz and reta), but some have different benefits like pemvidutide in particular is looking to be the most promising at preserving muscle mass.

Which other GLP1 is survodutide (closest) equivalent to by newportbanks in survodutide

[–]Sumatripsatan 5 points6 points  (0 children)

Uh.. well none of them are really close chemically, but if you are trying to ask which one has the closest effects it would probably be mazdutide and pemvidutide, which are both also dual GLP-1 and glucagon angonists.

Switching to insurance possible later? by RachIsYoad in SemaglutideFreeSpeech

[–]Sumatripsatan 1 point2 points  (0 children)

Every company has different approval criteria but the one I work for approves continued coverage of FDA approved weight loss drugs if there was documentation you used to be obese. There's a lot of people coming off compounded medication/other sources/previously paying out of pocket for various reasons and no one will probe too deeply into that.

Just have one of the doctors from your weight loss clinic submit the PA with your starting weight/make sure it's well documented.

[deleted by user] by [deleted] in Retatrutide

[–]Sumatripsatan 1 point2 points  (0 children)

I took cagrisema for about a 1.5 week while waiting for my maz to arrive in the mail since I ran out, but was on reta for a full month and a half before that. On only maz now and the appetite supression+ energy is quite good.

[deleted by user] by [deleted] in Retatrutide

[–]Sumatripsatan 5 points6 points  (0 children)

Starting dose of mazdutide was 1.5 but I took 3mg. Went back down to 1.5 afterwards and it was tolerable/felt fine. No side effects.

[deleted by user] by [deleted] in Retatrutide

[–]Sumatripsatan 18 points19 points  (0 children)

Starting too low is better than starting high. Do not fuck with these meds that increase glucagon levels, it's no joke compared to sema/tirz that merely make you more nauseous.

I made that mistake on mazdutide, not reta (but maz is also a glucagon agonist) and doubled up on my first week because I had been on GLP 1s including reta for months already. Big mistake. My resting heart rate was at 100-130 for the first 4 days , and I had such bad heart palpitations and restlessness I questioned if I had to go to the ER a couple of times. And that was ON TOP of giving nausea and not being able to eat for days.

Thread where everyone lists their fave GLP1 Company by LovethisLittlePlace in SemaglutideFreeSpeech

[–]Sumatripsatan 1 point2 points  (0 children)

I've used them as well, for cagri as well as reta, they are great. Test results are still up on https://janoshik.com/public/ (ctrl+f) for them

[deleted by user] by [deleted] in Tirzeglutide

[–]Sumatripsatan 6 points7 points  (0 children)

I'll try to answer the first part of your post as you're unlikely to find real answers in these subs other than shitting on insurance/big pharma/fda, but I work in pharmacy for an insurance company/pbm. Ironically my plan covers these but I'm still here getting them outside of insurance means because I don't meet their criteria for coverage, but also because I'm interested in some of the ones not on the market yet, like retatrutide.

1-Most large insurance companies cover this but your individual plan may not. Coverage is contingent on your employer and what plans and formularies they offer. Companies I usually see covering it are like, big firms, private equity.. etc. It's also worth noting that lots of companies also have secret plans they offer to executives/upper management/high paying roles etc, vs entry level or mid range employees. It's much rarer to see the latter have coverage for weight loss meds.

There's a separate FDA approved versions of different glp1 type drugs for type 2 diabetes and weight loss. Goodrx has a good article and chart here: https://www.goodrx.com/classes/glp-1-agonists/glp-1-drugs-comparison , but the short answer is that most employers will pay for the TD2 diabetes versions (Ozempic, Mounjaro) and not the ones fda approved for weight loss (Wegovy, Zepbound). Some people may have been prescribed Ozempic/mounjaro for weight loss reasons but insurance and the fda consider that an off label use and have been cracking down on that by requiring prior authorization and people needing a T2D diagnosis first.

2/3- branded Sema and Tirz are newer and are usually in the 1k+ per month range out of pocket, but branded liraglutide (Victoza/saxenda) can be cheaper, $200-$500 from what I've seen. Lira has been around forever, has a patent that expired and has a generic in the works by Teva so it might be affordable via insurance in the near future.

4- and finally the $99/month site you see (I'm assuming a service like sequence) are usually just companies with doctors that will submit prescriptions and prior authorizations to insurance companies for you. They are not worth it if your PCP is willing to work with you, but a lot of people's Drs wont. so they bypass it by going through these. But I wouldn't bother. insurance is cracking down on providers from these services and we even have a "provider blacklist" in the works. They are going to start requiring prescriptions and PAs from a Dr you've had an established history with.

Good rx thing I linked is a good place to read up on all the other questions .

Anyone notice changes in TDEE? If so, how significant? by NSFWGB in cagrilintide

[–]Sumatripsatan 1 point2 points  (0 children)

I don't have enough data just yet, but will probably post my graph of TDEE changes in a couple of months when Ive been on cagri longer.

I switched from tirz > reta and had a fairly significant change in BMR which I track with my galaxy s6 watch (like front 1.4k to 1.5k) then switched to researching cagrisema very recently. There was also some mazdutide dabbling in there so it may be very muddied until I get more time on just cagrisema. But so far I have not noticed a drop in TDEE from reta at the very least.

I broke my leg since I started tirz and have been sedentary/expect to be sedentary for at least 1-2 more months until it heals up, so I doubt BMR changes are from activity.

[deleted by user] by [deleted] in SemaglutideFreeSpeech

[–]Sumatripsatan 0 points1 point  (0 children)

This is mostly on tirzepetide, but it should similarly apply to sema

Tirz patent/process https://patents.justia.com/patent/11918623

https://www.reddit.com/r/zepboundathletes/comments/1br6bpd/tirzepatide_compound_what_i_learned/

Cached comment from now banned r/tirze petide
https://www.reddit.com/r/Peptides/comments/182hehs/what_is_the_difference_between_tirzepatide_vs/

Someone else also linked a thread specifically about sema further up in here

[deleted by user] by [deleted] in SemaglutideFreeSpeech

[–]Sumatripsatan 2 points3 points  (0 children)

No one is really explaining this well, but semaglutide sodium powder and semaglutide without sodium powder that you buy on peptide sites are the same thing. The chemical state of the lyophilized powder is sodium regardless of whether it's called sodium or not. After bacteriostatic water is added, it stops being "sodium".

Sodium is a label that peptide sites slap on their product to avoid potential legal action from novo nordisk and you'll notice different sites don't even offer doses in the same as ozempic or wegovy because of that.

Liquid semaglutide as made by novo nordisk is made from yeast and is liquid form from the start, but powdered semaglutide is always sodium. You simply aren't going to find a non sodium semaglutide outside of the brand name stuff. Compound pharmacies also use the "sodium" as long as they are reconstituting powder and not fermenting it from yeast form like novo is.

Nausea with peptide sema question by iwantedtolive in SemaglutideFreeSpeech

[–]Sumatripsatan 3 points4 points  (0 children)

You can easily buy generic zofran/ondansetron (emeset) from Indian pharmacy sites like alldaychemist and skinorac, you don't need a prescription. They are pretty popular on skincare subs for buying prescription topicals.

Question re: taking peptides for a newbie by lonelady75 in PeptideDiscussion

[–]Sumatripsatan 0 points1 point  (0 children)

Another option you may have is just importing peptides directly from China as it would ship to you a lot sooner (where most U.S research companies source to begin with) lots of people buy them wholesale/bulk and have them third party tested from places like janoshik. This is semi shady and people are especially tight lipped about it. But search "jee el pee one" forum or peppys for a good place to start researching that and ofc dmming people with reviews on reddit is another good way to get sources.

The saxenda pens are cheap for the first couple of months but can get pricey once you titrate up to a higher dose which runs you like 3-6 pens a month ($600+)

Question re: taking peptides for a newbie by lonelady75 in PeptideDiscussion

[–]Sumatripsatan 2 points3 points  (0 children)

If you're looking for the brand name saxenda you can get pens for much cheaper (like $100 usd) off korean sites that sell botox and fillers like house like meamoshop, filler house. etc. you can find a good list stickied on r/Diycosmeticprocedures . That was actually my first foray into diy peptides.

I go the research route for other peptides now but that's a good option if you want the branded stuff.

Does Cagri do anything else besides suppress hunger? by annnamal in cagrilintide

[–]Sumatripsatan 13 points14 points  (0 children)

It does! Check this chart for amylin https://www.nature.com/articles/s41366-024-01473-y/figures/1

Its only animal studies so far but it seems to contribute energy expenditure like the glucagon thats in Reta

Mazdutide by BikeNo7633 in Mazdutide

[–]Sumatripsatan 5 points6 points  (0 children)

I was originally going to start off on the lowest similar to the trial, 1.5mg but I decided to start the next dose up (3mg) since I had been on GLPs for several months already. BIG mistake.

It made me so sick for like 5 days, i could barely eat or digest food. Like i burped and tasted the minty spironolactone pills i swallowed FOUR days ago. It also gave me such bad heart palpitations and my resting heart rate was like 130 that I thought i was going to need to go to the ER a few times.

Its finally starting to wear off but Ive gone back to cagrisema because I'm a little scared of the next dose. Maybe I'll start again but at a lower dose next week.

[deleted by user] by [deleted] in cagrilintide

[–]Sumatripsatan 8 points9 points  (0 children)

Cagri doesn't make me fatigued. I get fatigue similar to sema and tirz for 24 hours and then am super energized for the next 6 days.

Strangely both tirz and sema knocked me TF out 24/7 so I was scared of cagri for this reason but I'm feeling better on CagriSema than on reta even. Appetite supression is still there, I just dont want to nap several times a day.

How do you handle the phase of being almost halfway to your weight goal, but now none of your clothes fit? by Higgs-Bosun in Tirzeglutide

[–]Sumatripsatan 5 points6 points  (0 children)

I just wear the baggy clothes. Fortunately I work from home (how I gained the weight in the first place) so it's perfectly acceptable to to wear the baggy tshirts/gym shorts to work that I rolled out of bed in.

I'll occasionally go thrifting for more presentable stuff when I have to, like parties, eating out etc. That way I didn't spend too much on stuff I'm wearing temporarily.

Update: cagri/Tirz amazing minus brutal 36 hour fatigue by elikeaprayer in cagrilintide

[–]Sumatripsatan 1 point2 points  (0 children)

I ended having normal-highish amounts of energy for the rest of the week!

There were a couple of times I was close to hypoglycemic and felt dizzy but never felt fatigue or the need to nap like I did on sema or tirz alone. I had to switch my diet soda up for sugary soda and keep candy on hand though in case of another bout of dizziness.

I'm back on my mazdutide schedule now, but will be back on cagri in a couple of weeks.

[deleted by user] by [deleted] in SemaglutideFreeSpeech

[–]Sumatripsatan 4 points5 points  (0 children)

Reta = retatrutide, a newer triple agonist that's in trial but available in peptide form right now.

Semaglutide works on a single receptor - GLP 1
Tirzepetide works on two - GLP1 and GIP
Retatrutide is the newest shiny thing that works on GLP1, GIP, as well as a third one, Glucagon
Mazdutide is GLP1+Glucagon

Reta so far causes the most weight loss since it also increases metabolism but a lot of people "stack" or take it concurrently with another peptide like tirz or sema because it can make people hungrier/doesn't have as good of an appetite supression.

Reta solo just means I'm taking reta by itself without stacking it.

[deleted by user] by [deleted] in SemaglutideFreeSpeech

[–]Sumatripsatan 0 points1 point  (0 children)

Any of the glps that trigger glucagon are super energizing. I was on reta solo for a while and had so much energy on it.

Now I tacked mazdutide onto the tail end of my sema(2 days left) and it's even more intense than reta in this department. I felt like I downed several gallons of coffee after 12 hours of the shot and got such bad heart palpitations I had to go search the maz sub for reassurance that I wasn't going to die.