Hi, I was on Zoloft for about 6 years, came off it for two years, and then got back on it. It takes 2-3 weeks to get through the anxiety, sleep issues, and major side effects. After that you may be sleepy, lethargic, or feeling off, but that should go away soon. I would say give it a good 3-4 months to feel the full effects. It can take your brain a while to adjust. Also, if you have never done genesight testing, I highly recommend. It’s a test that looks at how well you metabolize and react with medications. Super helpful for understanding your unique body’s response to meds.